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It was a small trial, just 18 rectal cancer patients, every one of whom took the same drug. But the results were astonishing. The cancer vanished in every single patient, undetectable by physical exam, endoscopy, PET scans or M.R.I. scans. Dr. Luis A. Diaz Jr. of Memorial Sloan Kettering Cancer Center, an author of a paper published Sunday in the New England Journal of Medicine describing the results ... said he knew of no other study in which a treatment completely obliterated a cancer in every patient. "I believe this is the first time this has happened in the history of cancer," Dr. Diaz said. Dr. Alan P. Venook, a colorectal cancer specialist at the University of California, San Francisco, who was not involved with the study, said he also thought this was a first. A complete remission in every single patient is "unheard-of," he said. These rectal cancer patients had faced grueling treatments – chemotherapy, radiation and, most likely, life-altering surgery that could result in bowel, urinary and sexual dysfunction. Some would need colostomy bags. They entered the study thinking that, when it was over, they would have to undergo those procedures because no one really expected their tumors to disappear. But they got a surprise: No further treatment was necessary. "There were a lot of happy tears," said Dr. Andrea Cercek, an oncologist at Memorial Sloan Kettering Cancer Center and a co-author of the paper. Another surprise, Dr. Venook added, was that none of the patients had clinically significant complications.
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Scientists have developed new technology that can turn seawater into clean drinking water in less than 30 minutes. Researchers based in Australia used a metal-organic framework (MOF), a type of lattice-like crystal, to desalinate water. The hollow framework of pores separates the salty solute within the brackish water or even saltier seawater, in a process known as molecular sieving. Under dark conditions, the framework absorbs salts and other impurities in the water in 30 minutes. The MOF itself is then regenerated for reuse in just four minutes, using sunlight to remove the adsorbed salts. The light-responsive MOF was used to filter harmful particles from water and generate 139.5 litres of clean water per kilogram of MOF per day. Scientists say their technology is more energy-efficient than current desalination practices, including reverse osmosis, and could provide potable water for millions globally. Water scarcity is one of the largest global risks in the upcoming years, according to the World Economic Forum (WEF). Thermal desalination processes by evaporation using solar energy are widely used to produce fresh water, but can be highly energy intensive. 'Sunlight is the most abundant and renewable source of energy on Earth,' said Professor Huanting Wang ... at Monash University in Australia. 'Our development of a new adsorbent-based desalination process through the use of sunlight for regeneration provides an energy-efficient and environmentally-sustainable solution for desalination.'
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Research shows that acts of kindness make us feel better and healthier. Kindness is also key to how we evolved and survived as a species, scientists say. We are hard-wired to be kind. Psychology professor Sonja Lyubomirsky has put that concept to the test in numerous experiments over 20 years and repeatedly found that people feel better when they are kind to others, even more than when they are kind to themselves. “Acts of kindness are very powerful,” Lyubomirsky said. In one experiment, she asked subjects to do an extra three acts of kindness for other people a week and asked a different group to do three acts of self-kindness. The people who were kind to others became happier and felt more connected to the world. The same occurred with money, using it to help others versus helping yourself. Lyubomirsky said she thinks it is because people spend too much time thinking and worrying about themselves and when they think of others while doing acts of kindness, it redirects them away from their own problems. Oxford’s [Oliver] Curry analyzed peer-reviewed research like Lyubomirsky’s and found at least 27 studies showing the same thing: Being kind makes people feel better emotionally. But it’s not just emotional. It’s physical. Lyubomirsky said a study of people with multiple sclerosis ... found they felt better physically when helping others. She also found that in people doing more acts of kindness that the genes that trigger inflammation were turned down more than in people who don’t.
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Dogs have such exquisitely sensitive noses that they can detect bombs, drugs, citrus and other contraband in luggage or pockets. Is it possible that they can sniff out even malaria? And when might that be useful? A small pilot study has shown that dogs can accurately identify socks worn overnight by children infected with malaria parasites even when the children had cases so mild that they were not feverish. In itself, such canine prowess is not surprising. Since 2004, dogs have shown that they can detect bladder cancer in urine samples, lung cancer in breath samples and ovarian cancer in blood samples. Trained dogs now warn owners with diabetes when their blood sugar has dropped dangerously low and owners with epilepsy when they are on the verge of a seizure. Other dogs are being taught to detect Parkinsons disease years before symptoms appear. The new study ... does not mean that dogs will replace laboratories. But for sorting through crowds, malaria-sniffing dogs could potentially be very useful. Some countries and regions that have eliminated the disease share heavily trafficked borders with others that have not. For example, South Africa, Sri Lanka and the island of Zanzibar have no cases but get streams of visitors from Mozambique, India and mainland Tanzania. And when a region is close to eliminating malaria, dogs could sweep through villages, nosing out silent carriers people who are not ill but have parasites in their blood that mosquitoes could pass on to others.
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Every time somebody flushes a toilet in Mannheim, they contribute to ecological shipping. Since March 2025, the German city's wastewater treatment plant has been feeding an experiment of global relevance: Transforming sewage gases into green methanol, a cleaner, nearly-carbon-neutral alternative to heavy fuel oil. The pilot, known as Mannheim 001, is the first full case study of how human waste can be captured, processed and converted into fuel powerful enough to propel cargo ships across oceans. "It's the first time the entire value chain – from sewage to finished methanol – has been demonstrated," says David Strittmatter, co-founder of Icodos, the start-up behind the project. Wastewater plants produce sludge – the thickened residue left after sewage is treated and cleaned. Mannheim's plant ferments this sludge in oxygen-free tanks, yielding biogas rich in methane and carbon dioxide, which is usually burned for heat or flared off. Icodos' innovation is to clean and upgrade that gas. "The sewage gas is dried, desulfurized, and then the carbon dioxide is separated from the rest," Strittmatter explains. Using renewable electricity, the captured carbon dioxide is then combined with hydrogen through a catalytic process to form methanol – a liquid fuel that can run ship engines. According to Icodos, scaling sewage-to-methanol worldwide could cover the entire fuel demand of the global shipping sector.
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Insect-eating bird populations in France appear to be making a tentative recovery after a ban on bee-harming pesticides, according to the first study to examine how wildlife is returning in Europe. Neonicotinoids are the world's most common class of insecticides, widely used in agriculture and for flea control in pets. By 2022, four years after the European Union banned neonicotinoid use in fields, researchers observed that France's population of insect-eating birds had increased by 2%-3%. These included blackbirds, blackcaps and chaffinches, which feed on insects as adults and as chicks. The results could be mirrored across the EU, where the neonicotinoid ban came into effect in late 2018, but research has not yet been done elsewhere. The lead researcher, Thomas Perrot from the Fondation pour la recherche sur la biodiversitĂ© in Paris, said: "Even a few percentage [points'] increase is meaningful – it shows the ban made a difference. Our results clearly point to neonicotinoid bans as an effective conservation measure for insectivorous birds." Like the EU, the UK banned neonicotinoids for outdoor general use in 2018, although they can be used in exceptional circumstances. They are still widely used in the US, which has lost almost 3 billion insectivorous birds since the 1970s. Sustainable farming, which reduced pesticides and restored semi-natural habitats, would help bird populations recover.
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In Finland, kindergartens are exposing children to more mud, wild plants and moss - and finding changes to their health that show how crucial biodiversity is to wellbeing. At Humpula daycare centre in Lahti, north of Helsinki, children are encouraged to get muddy. Across Finland, 43 daycare centres have been awarded a total of ₏1m (Ł830,000) to rewild yards and to increase children's exposure to the microscopic biodiversity – such as bacteria and fungi – that lives in nature. We already know that access to the outdoors is important for children and their development. But this study goes one step further. It is part of a growing body of research linking two layers of biodiversity. There is the outer layer – the more familiar vision of biodiversity, made up of soil, water, plants, animals and microbial life, that lives in the forest, playground (or any other environment). And then there is the inner layer: the biodiversity that lives within and upon the human body, including the gut, skin and airways. Increasingly, scientists are learning that our health is intimately linked to our surroundings, and to the ecological health of the world around us. The plants, dead wood and soil in the daycare centre have all been specially selected for their rich micro-biodiversity. They have also dug up and imported a giant live carpet of forest floor, 20-40cm deep and 10 metres square. It has blueberries, lingonberries and moss growing on it, to encourage the children to forage, find bugs and learn about nature.
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After a decade behind bars, it wasn't the fields that stretched for kilometers around him that struck Nicolas when he first set foot on the farm. It was the smell. "I've been through six different jails and they all reeked. But you get used to it and forget it ever smelled bad – until you get out. Here, you can breathe in and out fully," he says, gesturing to the light-stone buildings and tractor parked in the courtyard. Located in Coucy-le-Château-Auffrique, a small village in the north of France, the Moyembrie farm hosts inmates through a detention program run by a small nonprofit. Along with nine others, Nicolas came to spend the last stretch of his sentence beyond prison walls. At Moyembrie, time is served differently. There are no bars, no cells, and inmates can go into town during their time off. All staff are social workers directly employed by the farm – the first facility of its kind to receive a contract from the Ministry of Justice to host inmates. Residents work four hours each morning. They tend to vegetable plots, lead goats from the barn to the field, or cook meals shared in the common room. All inmates at the farm are able to pursue classes and training programs. Some are even run on-site by volunteers, like lessons for the driver's license written exam. Nicolas, who has never had his driver's licence, attends these every week, hoping it will help him secure a job. Over half of the inmates who go there are working or in training three months after release and all leave with stable accommodation.
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It wouldn't be wrong to say Sam Shoemaker crossed the ocean on a mushroom. This August, the Californian artist launched his 14-foot kayak off Catalina Island and paddled for 12 hours across the 26.5-mile Catalina Channel to San Pedro. The brownish-white boat itself [was] "a boat made entirely from a single mushroom growing outside my studio," Shoemaker explains – the world's largest mushroom boat. He built it from wild Ganoderma polypore collected near his LA studio, propagated in a hemp-and-sawdust substrate for about four weeks, molded into kayak form and dried until it became "a strong, hydrophobic and inert, cork-like material." Mycelium, the interconnected root network of a fungus such as Ganoderma polypore, can grow to hundreds of acres. The boat was sealed with locally sourced beeswax, using no synthetic materials. Shoemaker's multiyear project wasn't commercial – he is simply interested in demonstrating mushrooms' potential. His invention is part of AquaFung, a term coined – and a movement inspired – by artist Phil Ross that hopes to one day replace Styrofoam and other materials that go into water with fungi, as part of the nonprofit Open Fung. In their quest, Shoemaker and Ross are members of a sprouting global community of artists, engineers, high-end designers and environmentalists, intent on producing sustainable inventions from mushrooms. For Ross, mycelium is not just a material but a mystery and companion.
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Walking into Brightworks could be a shock for helicopter parents. The K-12 school is alive with invention, autonomy and what founder Gever Tulley calls "the energy of a big multi-generational family household." Therefore there are no traditional grades or classes at Brightworks. Students are grouped into "bands" by interest and maturity, not by age. There are no teachers – just "collaborators," and parents are invited to visit and join as they please. Agency is woven into every part of Brightworks' ecosystem. Students move freely through the buildings. "The first instinct can't be, â€Where are you supposed to be?'" Tulley explains. "You have to assume they're on a mission – maybe to grab a wrench from the shop or to take a walk. That's part of the culture here." Students can't hide behind textbooks or screens; each semester, they must propose, plan and find collaborators for their own project – and eventually present it to the entire school, known as the "Brightworks family." Tulley believes this kind of learning – driven by curiosity – pays off for life: "We see students as heroes on their own journey." His aim is also to prepare kids for the future. "Twenty years from now, every industry will need small teams of highly specialized people solving complex problems," he says – people who can also communicate and collaborate well. Brightworks graduates have been accepted at top-tier universities, including Harvard.
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Collaborating with robotics engineers and Italian 3D printer manufacturers, a Japanese company is building "homes of earth" made primarily from soil. Lib Work, Ltd. completed their first 3D-printed earth home in Yamaga, Kumamoto on July 22, calling their creative process "uncharted territory where tradition and convention offered no guide". With an eye toward recycling, sustainability, and reduced carbon emissions, Lib Work focused on combining 3D-printing with natural materials enhanced for strength, constructibility, and design quality. The walls of the completed Lib Earth House Model B use no cement (which produces industrial waste). Instead, they utilized only naturally derived materials with soil as the primary component to create sustainable earthen walls. Compared to the previous model (Model A) that used some cement, the building's strength has improved approximately fivefold while significantly reducing CO2 emissions from the manufacturing process itself. The walls contain cutting-edge sensors as part of a wall condensation monitoring system that monitors in real-time the temperature and humidity inside the walls. This system enables the house to manage its own condition by detecting condensation in advance to maintain a long-lasting, comfortable living environment. Additionally, the homes include remote operation of air conditioning, lighting, and bath controls via smartphone or dedicated monitor. It also features an off-grid energy system.
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While trying to come up with a pesticide solution to kill off bollworms, Dr Robert Mensah had his eureka moment. It was the 90s, and in Australia bollworms were devastating cotton farms. He experimented and eventually came up with a simple food spray, "a mixture of food ingredients, yeast and sugar-based, diluted in water and applied to crops. It emits an odour which is picked up by beneficial predatory insects and attracts them to the fields where they kill pests." It was the beginning of an international grassroots campaign, in which Mensah has worked with various charities to teach people about this sustainable farming method. Ever since the dangerous side effects of pesticides became widely known, alternatives have been sought. This approach to farming, which reduces our reliance on pesticides, is called integrated pest management. In 2005, Mensah took food sprays to Benin, where the Pesticide Action Network (PAN UK) was helping farmers transition to organic farming. There, the misuse of chemical pesticides was seriously damaging people's health. The food sprays – cheap, safe and effective – caught on with farmers in Benin where thousands now use the technique. From there, Mensah took food sprays to southern Ethiopia, where they were also trialled successfully on vegetables ... and then to Vietnam where they were used successfully on maize. Another charity, Better Cotton, is now trialling food sprays in India ... where they've trained 214,000 farmers to use sprays.
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In 2021, Kristen Magnuson had to make a secret deal to continue a staple of her daily routine: swimming at her local outdoor pool. During the pandemic, the state of Washington required a vaccine passport to gain access to public spaces such as restaurants, movie theaters, and gyms. Ms. Magnuson chose not to get vaccinated. So the mother of two made a covert arrangement with gym staff. She could bypass the lobby by sneaking in through a back door. Ms. Magnuson was grateful, but she felt like a second-class citizen. Now she has a plea: Can we talk about what we went through? She isn't opposed to vaccines – her husband and children got them. She and others are asking: What would America do differently if the country could have a do-over, or faced a similar challenge in the future? Ms. Magnuson ... isn't ready to absolve top officials until they show "a recognition of harms." "I was surprised when some politicians and doctors said that those who remain unvaccinated should not be treated if they fall ill. People were not â€bad' or â€COVidiots' if they contracted COVID-19; they were human," [Dr. Monica] Gandhi wrote. "There is absolutely no place for stigma, judgment, and a shame-based approach in public health." The former NIH director [Dr. Francis Collins] proposed, instead, a reckoning modeled on South Africa's Truth and Reconciliation Commission in the aftermath of apartheid. "That means people coming forward and confessing what they did that was harmful in public and asking for forgiveness," said Dr. Collins, who was appointed by President Obama and served as a science adviser to Biden. "That's very different than just amnesty."
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Certain kinds of gut microbes absorb toxic Pfas "forever chemicals" and help expel them from the body via feces, new first-of-its-kind University of Cambridge research shows. The findings are welcome news as the only options that exist for reducing the level of dangerous Pfas compounds from the body are bloodletting and a cholesterol drug that induces unpleasant side effects. The microbes were found to remove up to 75% of some Pfas from the gut of mice. Several of the study's authors plan to develop probiotic dietary supplements that boost levels of helpful microbes in the human gut, which would likely reduce Pfas levels. "If this could be used in humans to create probiotics that can help remove Pfas from the body then this would be a nicer solution in that it wouldn't have so many side effects," said Anna Lindell, Cambridge doctoral student and a co-author of the study. Pfas are a class of about 15,000 compounds most frequently used to make products water-, stain- and grease-resistant. They have been linked to cancer, birth defects, decreased immunity, high cholesterol, kidney disease and a range of other serious health problems. They are dubbed "forever chemicals" because they do not naturally break down in the environment. The microbes [in the study] largely addressed "long-chain" Pfas, which are larger compounds and more dangerous than smaller "short chains" because they stay in the body longer.
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In Stockholm, Stina Larsson, 98, stood among fragrant lilacs, lilies and lavender, inspecting the garden that she has tended for more than 40 years. Ms. Larsson's garden, situated on a postage stamp of land beside the Karlbergs Canal, is one of more than 7,000 garden allotments, known as koloniträdgĂĄrdar, in Stockholm. The gardens, established as part of a social movement around the turn of the 20th century, offer city dwellers access to green space and a reprieve from crowded urban life. Though most are modest in size – Ms. Larsson's garden is about 970 square feet – koloniträdgĂĄrdar are prized for providing a rare kind of urban sanctuary, a corner of the city where residents can trade pavement for soil, and the buzz of traffic for birdsong. The garden programs were specifically designed to improve the mental and physical health of city dwellers. The idea was that a working-class family would be able to spend the summer there and work together but also have some leisure and fun. Cecilia Stenfors ... at Stockholm University, said her research shows that those who frequently visit green spaces, whether a forest or a koloniträdgĂĄrd, "have better health outcomes, in terms of fewer depressive symptoms, less anxiety, better sleep and fewer feelings of loneliness and social isolation." These positive effects can be particularly pronounced in older people and can help combat symptoms of age-related mental and physical decline.
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Not everyone pines for the days without cell phones, but what about social media? Would you erase social media from the history books if you could? If you said yes, you share the feelings of a staggering 46% of teenage respondents to a recent survey from the British Standards Institution (BSI), which also found that 68% of respondents said they felt worse when they spend too much time on their socials. Enter The Offline Club, (who ironically have 530,000 followers on Instagram) a Dutch social movement looking to create screen-free public spaces and events in cafes to revive the time before phones, when board games, social interaction, and reading were the activities observed in public. They also host digital detox retreats, where participants unplug from not only their smartphones, but computers too, and experience a life before the internet. BSI's research showed that out of 1,290 individuals aged 16-21, 47% would prefer to be young in a world without the internet, with 50% also saying a social media curfew would improve their lives. The Offline Club is taking advantage of this rising cross-cultural awareness and helps its followers replace "screen time with real time." Their founders envision a world where time spent in public is present and offline. It started in Amsterdam, but Club chapters quickly organized in Milan, Berlin, Paris, London, Barcelona, Brussels, Antwerp, Dubai, Copenhagen, and Lisbon. Anyone can start a club in a city.
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When Rodolfo "Rudy" Reyes went diving in the Cayman Islands in 2015, the experience changed his life. The highly decorated veteran had logged thousands of dives as a Special Ops Force Recon Marine in 18 years of service. But, as Reyes recalls, "As combat divers we operate at night, pushing 200 pounds of equipment, carrying massive weapons. It's very stressful and we focus on the mission – taking on the enemy." In the Caribbean, Reyes dove for the first time during daytime at his own pace, guided by his friend Jim Ritterhoff, who worked with the Central Caribbean Marine Institute. At the time, Reyes was struggling with depression, post-traumatic stress and substance abuse. "I had a really hard drug habit after all these intense combat tours," he admits, but diving in the Caymans, surrounded by vibrant marine life, reignited a sense of wonder. "It brought me back to life. It inspired the same kind of protective spirit and willingness to go fight in the battlefield that I used in the Marine Corps, but now I wanted to use that passion to fight for ocean conservation." In 2016, Reyes, Ritterhoff and Keith Sahm co-founded Force Blue, a nonprofit that recruits veterans – especially Navy SEALs and Special Operations divers with military dive training – to channel their skills into marine conservation. "We're learning to transfer combat diving expertise into protecting and providing refuge for this incredible aquatic environment," Reyes explains.
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Hemp is one of the most sustainable materials available to manufacturers because it's cheap to grow, uses little water, doesn't need any toxic pesticides, and can absorb more carbon than trees. Hemp batteries have their own advantages, too. These batteries use lighter and more widely available materials like sulfur, boron, and hemp instead of the heavy metals used in traditional lithium-ion batteries. Some EVs use a device called a supercapacitor, which stores energy through static electricity rather than a chemical reaction, like in conventional batteries. In these batteries, a material called graphene is used. But graphene is expensive. To create ... "cannabis cars," scientists use hemp bark – a waste product created by cannabis plants – and cooked it to make a substance that resembles graphene. Hemp lasts longer than graphene. It also stores more power and is easy to source. Son Nguyen, Bemp Research's founder, told EnergyTech that the company's lithium-sulfur battery can help solve shortages in the EV battery supply chain. "Sulfur is very abundant. Boron is also relatively abundant, with the biggest boron mine being in California," Nguyen said. "Being an American company, our focus right now is to make batteries for American electric vehicles, and we do not see any supply chain problems. Bemp batteries are less reliant on rare earth metals from around the globe and thus will help U.S. national security."
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Parents with small children, teenagers, and senior citizens clustered outside the door and waited to hear their ticket numbers called. They weren't there for books. They came to shop for groceries. Connected to the [Enoch Pratt Library], the brightly painted market space is small but doesn't feel cramped. Massive windows drench it in sunshine. In a previous life, it was a cafĂ©. Now, shelves, tables, counters, and a refrigerator are spread out across the room, holding a mix of produce and shelf-stable goods. On any given day, there's a range of produce, like collard greens, apples, onions, radishes, potatoes, and cherry tomatoes, plus eggs, orange juice, rice, bread, and treats like cookies and peanut butter crackers. As they exited, shoppers did not need to pull out their wallets: No one pays at Pratt Free Market. Launched in the fall of 2024, Pratt Free Market opens its doors every Wednesday and Friday and serves around 200 people per day. Anyone can pick up food at the store without providing identification or meeting income requirements. For Baltimore residents, 28 percent reported experiencing food insecurity last year–twice the national average. Pratt Free Market ... offers a mix of everything–from healthy, fresh produce to sweets. And every fourth Friday, the marker turns into "Pantry on the Go!", a farmers' market-style setup outside the library that offers fruits and vegetables. Last month ... they handed out onions, sweet potatoes, watermelons, celery, and apples.
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She has been at the bedside of over 1,000 people globally in their last moments of life–from her home in the U.S. to Thailand and Zimbabwe. O'Brien, a registered nurse, had an impulse to move into hospice care over two decades ago and has since worked as an oncology nurse and a death doula, supporting those at the end of life. O'Brien's recent book, The Good Death, aims to normalize the realities of death and the need to plan for the end. At the end of life, many people share what they didn't do but knew they always wanted to do, O'Brien says."We all are here for a purpose, and we all have gifts, and when we don't share them and act upon those, that's where the huge regret comes," O'Brien says. Not "dipping into the unknown" or trying something new is a factor of having an abundance mindset, she says. When we consider our time sacred and limited, we are less afraid to take action on something that may excite us. "One of the things we don't know is how many days we have," she says. "When you get that feeling, or you have something that you want to do, don't let your ego, the fear part of you, shut it down." Many people at the end of life regret not being vulnerable enough to let themselves be loved and give love. They often share that they could not reach a level of forgiveness with someone else or themselves, O'Brien says. It's essential to extend ourselves grace, know when to take ownership, and release guilt, she says. O'Brien encourages patients to envision the time they're struggling to let go of and ask themselves if they did what they could in the moment with the information and resources they had.
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