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It was a small trial, just 18 rectal cancer patients, every one of whom took the same drug. But the results were astonishing. The cancer vanished in every single patient, undetectable by physical exam, endoscopy, PET scans or M.R.I. scans. Dr. Luis A. Diaz Jr. of Memorial Sloan Kettering Cancer Center, an author of a paper published Sunday in the New England Journal of Medicine describing the results ... said he knew of no other study in which a treatment completely obliterated a cancer in every patient. "I believe this is the first time this has happened in the history of cancer," Dr. Diaz said. Dr. Alan P. Venook, a colorectal cancer specialist at the University of California, San Francisco, who was not involved with the study, said he also thought this was a first. A complete remission in every single patient is "unheard-of," he said. These rectal cancer patients had faced grueling treatments – chemotherapy, radiation and, most likely, life-altering surgery that could result in bowel, urinary and sexual dysfunction. Some would need colostomy bags. They entered the study thinking that, when it was over, they would have to undergo those procedures because no one really expected their tumors to disappear. But they got a surprise: No further treatment was necessary. "There were a lot of happy tears," said Dr. Andrea Cercek, an oncologist at Memorial Sloan Kettering Cancer Center and a co-author of the paper. Another surprise, Dr. Venook added, was that none of the patients had clinically significant complications.
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Scientists have developed new technology that can turn seawater into clean drinking water in less than 30 minutes. Researchers based in Australia used a metal-organic framework (MOF), a type of lattice-like crystal, to desalinate water. The hollow framework of pores separates the salty solute within the brackish water or even saltier seawater, in a process known as molecular sieving. Under dark conditions, the framework absorbs salts and other impurities in the water in 30 minutes. The MOF itself is then regenerated for reuse in just four minutes, using sunlight to remove the adsorbed salts. The light-responsive MOF was used to filter harmful particles from water and generate 139.5 litres of clean water per kilogram of MOF per day. Scientists say their technology is more energy-efficient than current desalination practices, including reverse osmosis, and could provide potable water for millions globally. Water scarcity is one of the largest global risks in the upcoming years, according to the World Economic Forum (WEF). Thermal desalination processes by evaporation using solar energy are widely used to produce fresh water, but can be highly energy intensive. 'Sunlight is the most abundant and renewable source of energy on Earth,' said Professor Huanting Wang ... at Monash University in Australia. 'Our development of a new adsorbent-based desalination process through the use of sunlight for regeneration provides an energy-efficient and environmentally-sustainable solution for desalination.'
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Research shows that acts of kindness make us feel better and healthier. Kindness is also key to how we evolved and survived as a species, scientists say. We are hard-wired to be kind. Psychology professor Sonja Lyubomirsky has put that concept to the test in numerous experiments over 20 years and repeatedly found that people feel better when they are kind to others, even more than when they are kind to themselves. “Acts of kindness are very powerful,” Lyubomirsky said. In one experiment, she asked subjects to do an extra three acts of kindness for other people a week and asked a different group to do three acts of self-kindness. The people who were kind to others became happier and felt more connected to the world. The same occurred with money, using it to help others versus helping yourself. Lyubomirsky said she thinks it is because people spend too much time thinking and worrying about themselves and when they think of others while doing acts of kindness, it redirects them away from their own problems. Oxford’s [Oliver] Curry analyzed peer-reviewed research like Lyubomirsky’s and found at least 27 studies showing the same thing: Being kind makes people feel better emotionally. But it’s not just emotional. It’s physical. Lyubomirsky said a study of people with multiple sclerosis ... found they felt better physically when helping others. She also found that in people doing more acts of kindness that the genes that trigger inflammation were turned down more than in people who don’t.
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Dogs have such exquisitely sensitive noses that they can detect bombs, drugs, citrus and other contraband in luggage or pockets. Is it possible that they can sniff out even malaria? And when might that be useful? A small pilot study has shown that dogs can accurately identify socks worn overnight by children infected with malaria parasites even when the children had cases so mild that they were not feverish. In itself, such canine prowess is not surprising. Since 2004, dogs have shown that they can detect bladder cancer in urine samples, lung cancer in breath samples and ovarian cancer in blood samples. Trained dogs now warn owners with diabetes when their blood sugar has dropped dangerously low and owners with epilepsy when they are on the verge of a seizure. Other dogs are being taught to detect Parkinsons disease years before symptoms appear. The new study ... does not mean that dogs will replace laboratories. But for sorting through crowds, malaria-sniffing dogs could potentially be very useful. Some countries and regions that have eliminated the disease share heavily trafficked borders with others that have not. For example, South Africa, Sri Lanka and the island of Zanzibar have no cases but get streams of visitors from Mozambique, India and mainland Tanzania. And when a region is close to eliminating malaria, dogs could sweep through villages, nosing out silent carriers people who are not ill but have parasites in their blood that mosquitoes could pass on to others.
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Since the Israel-Hamas war, relationships between some students have been nowhere near brotherly, let alone collegial. Some students just aren't accustomed to contrary or controversial ideas and believe that even hearing them is harmful. What hasn't made headline news is the spike in civil discourse initiatives at campuses. Here's one gauge. At the Institute for Citizens & Scholars, a coalition of College Presidents for Civic Preparedness went from a handful of participants prior to Oct. 7, 2023, to well over 100 afterward. The likes of Harvard, Yale, the Massachusetts Institute of Technology, and the University of Michigan in Ann Arbor have launched civil discourse initiatives since the deadly Hamas attack that sparked the Israeli invasion of Gaza. One success story is the Dialogue, Inclusion, and Democracy (DID) Lab at Providence College in Rhode Island, run by Dr. Bevely and Professor Nick Longo. "With Mutual Respect" events feature two people on opposing sides of an issue. Panelists don't so much debate as endeavor to foster mutual understanding. In December 2020, Vanderbilt [University's] women's basketball team elected to protest for racial justice by staying inside the locker room during the national anthem. Vanderbilt ... facilitated structured dialogue between the basketball players and military veterans on the Nashville, Tennessee, campus. Some athletes shared experiences of racism and discrimination. Young men and women, some of whom had combat experience, explained why they felt so strongly about serving their country. The culture of civil discourse needs to be rooted in a relationship of trust. "If as a student, I'm challenging something, or I say something controversial, I'm going to have to trust you that you're not excluding me," says [Chancellor] Dr. Diermeier.
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Community currencies – alternative forms of money sometimes also referred to as local or regional currencies – are as diverse as the communities they serve, from grassroots time-banking and mutual credit schemes to blockchain-based Community Inclusion Currencies. Local currencies were common until the 19th century, when the newly emerging nation states transitioned to a centralized system of government-issued money as a way of consolidating their power and stabilizing the economy. Far from being a neutral system of exchange, a currency is a tool to achieve certain goals. Inequality and unsustainability are baked into our monetary system, which is based on debt and interest with practically all the money ... being created by private banks when issuing loans. Well-designed community currencies eliminate two main sources of financial inequality: money's perceived inherent value and the interest rates, which both incentivize people to hoard their money. Like the pipes that bring water to your house, money is the conduit that gives you access to goods and services. The value of money is created in the transaction. In 2015 it was estimated that almost 400 of them are active in Spain alone, and across Africa blockchain-backed systems, like the Sarafu in Kenya, help underserved communities do business without conventional money. Elsewhere, local currencies like the Brixton pound in the U.K. or BerkShares in Massachusetts are a way to keep money in the community, buffering it against the pressures of a globalized economy.
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In 2015, [Jo] Nemeth had quit her community development job, given the last of her money to her 18-year-old daughter Amy and closed her bank account. "I was 46, I had a good job and a partner I loved, but I was deeply unhappy," Nemeth says. "I'd been feeling this growing despair about the economic system we live in." Her "lightbulb moment" came when her parents ... gave her a book about people with alternative lifestyles. "When I read about this guy choosing to live without money, I thought, â€Oh my God, I have to do that!'" The first thing Nemeth did was write a list of her needs. "I discovered I really didn't need much to be comfortable. Then I just started ... figuring out how I could meet my needs without having any negative impacts." For the first three years, Nemeth lived on a friend's farm, where she built a small shack from discarded building materials before doing some housesitting and living off-grid for a year in a "little blue wagon" in another friend's back yard. Instead of paying rent, Nemeth cooks, cleans, manages the veggie garden and makes items such as soap, washing powder and fermented foods. And she couldn't be happier. She soon started tapping into the "gift economy" more deeply, giving without expecting anything in return, receiving without any sense of obligation. "That second part took a while to get used to," she says. "It's very different to bartering or trading, which involves thinking in a monetary, transactional way: I'll give you this if you give me that. I actually feel more secure than I did when I was earning money," she says, "because all through human history, true security has always come from living in community and I have time now to build that â€social currency'. To help people out, care for sick friends or their children, help in their gardens. That's one of the big benefits of living without money."
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An eco-friendly fitness trend that started in 2016 is now growing in popularity with its own world championship competition in Italy. Originating in Sweden, when Erik Ahlström began picking up litter while jogging in Stockholm, the term is a combination of the Swedish word plocka, which means "to pick up", and the English word "jogging". The activity of picking up litter while on your outdoor jog, has spread to other countries, and now an estimated 2 million people â€plog' regularly in over 100 countries. The workout adds bending, squatting, and stretching to the main action of running–with â€pliking' being the latest offshoot for hikers who want to clean up the trail. The third annual World Plogging Championship in 2023, resulted in approximately 6,600 pounds of litter (3,000 kg) removed from the environment around the city of Genoa. Later this year, a British team will be traveling to the competition with the goal of running the farthest and picking up the most rubbish. Claire Petrie recently kick-started her training with community events in her hometown of Bristol. "I love that you help the environment, the planet and meet new people," said the 48-year-old personal trainer who became passionate about combining health and the environment. "We want to grow plogging in as many cities as possible." During the past year, Claire's group, which plans to expand into other areas in Bristol but currently has an average of 9 people joining in, collected 220 pounds of trash (100 kg).
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A 2021 study published in Explore suggests that past life experiences have been reported across various parts of the world. Children often begin recalling past life memories around the age of 2 and gradually stop discussing them by about 9, when they're well into their schooling years. Many children describe events, names, families or places from their alleged past life. Many also recall violent or unnatural deaths in their previous life, and about 20% participants mention an "intermission" period between lives, with an average gap of 16 months between a previous death and rebirth. Children can also display skills or behaviors they haven't been taught, such as xenoglossy (speaking a language they've never learned). Research on near-death experiences, published in the Journal of Near-Death Studies, also suggests that survivors sometimes experience past-life memories, similar to those that young children in past-life recollection studies recall. Mr. David Moquin ... was in a coma and hospitalized with double pneumonia. "During that time, I experienced at least two events that felt like past lifetimes. The one that has haunted me for the past 24 years was that of burning to death in an airplane crash. Many years later a psychic told me that in my last lifetime I died landing a fighter plane on an odd single digit day in November 1944. I was born December 21, 1944," Moquin explains. "My daughter, hearing the recording of the reading, googled and found that Captain Fryer was the only pilot that died on an odd single digit day that November, and that he died trying to land his burning P-51 Mustang. My favorite plane has always been the P-51. The model sits on my desk. My daughter asked me questions and I seemed to know the names of my wing commander, squadron commander, mother and father."
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"Hospitals are the ugliest places in the world," says Jacques Herzog. "They are a product of blind functionalist thinking, while neglecting basic human needs." Welcome to Zurich's remarkable new children's hospital, the Kinderspital – or "Kispi" for short – a 14-year endeavour to revolutionise how we think about the architecture of healing. It is not trying to be a fancy hotel, like some private hospitals. It is just a place where simple things like the quality of light and views, the scale and proportion of spaces and the texture of materials have been thought about with immense care, and honed to make the experience as pleasant as possible for everyone. The firm [Herzog & de Meuron] completed an impressive, yet oddly undersung, rehabilitation clinic in Basel in 2002, and is now building a huge amoeba-shaped hospital in Denmark as well as a terracotta-clad ziggurat teaching hospital in San Fransisco. "I am totally convinced that architecture can contribute to the healing process," [Herzog says]. The 600-strong practice has been quietly tackling the topic of healthcare for the last two decades. Kispi ... is unlike any other hospital. The rooms have a more domestic feel than typical hospital rooms, like being in the attic of an alpine chalet. They have big picture windows and clever window seats that can be pulled out to become beds, giving weary parents a place to sleep. Having a sloped wooden roof and natural light makes a huge psychological difference when you're lying in bed staring at the ceiling all day. Fun porthole windows at child height can be opened for natural ventilation, while every room has an en suite bathroom. Wooden floors add a sense of warmth in contrast to the usual stark vinyl – and they're just as hygienic, coated with ultra-hardwearing polyurethane. "We've tried to make the architecture address the curiosity of children," says Christine Binswanger, partner in charge of the project.
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Revving their engines, the Bikers Against Child Abuse love to ride, and they love to make a difference by helping children who have been abused. It is about giving them back some of the power balance that has been stolen from them, giving them back some of the childhood that has been stolen from them," says Bikers Against Child Abuseâ€s Tom Goudreau, whose road name is â€Motown'. The Bikers Bikers Against Child Abuse – BACA for short – has chapters all over North America and around the world. Children they help are welcomed in a special ceremony and they can reach out for help whenever they need it. "They get a road name like we have, and two primaries who will be responsible, 24/7, for that child whenever they need it," Motown says. "We'll be there at three o'clock in the morning, if necessary." It's something Motown wishes he had had as a child after being abused by a family member. "A lot of us are survivors," he says. "The number one thing that people say to us around the world is, I wish you were there when I was a kid. That's usually with a tear in their eye. Child abuse is epidemic. We need to face the facts. This happens everywhere. That's why we're in 19 countries around the world because child abuse is everywhere." "It's tough when you see a small child who's wounded, needs help, but when you see them, change from that small child to somebody who's empowered, it's the best feeling in the world," [a member] adds.
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A wave of local democracy is sweeping across Europe. On the streets of Hull ... democracy is coming to life through people's assemblies. Assemblies are public meetings where local people get together to discuss and decide on a specific issue, without political interference or hidden agendas. These assemblies can help us fundamentally rethink how we make decisions in our society, and create strong, active communities in the process. To survive ecological breakdown and the collapse of our failing economy, we need both, urgently. The culture war has gained a lot of ground. Overcoming these divisions is one of our biggest, most pressing challenges. Through assemblies, it's possible to form self-organising communities where we lift each other out of the conditions that these ideologies prey on. Where we are forced to work alongside people we disagree with or even dislike, and organise positive initiatives that feed us, lower our energy bills, give us purpose and contribute to a stronger community spirit. Our assembly ground rules ask us to look for what we have in common, and there is a wealth of agreement to be found if you care to look for it. Cooperation Hull is holding Neighbourhood Assemblies across the city, and in each one we are learning what happens when a room full of strangers upend social norms to break bread, hold hands (an ice-breaker) and voice their honest opinions on the most important questions of our time. Soon we will launch the first citywide assembly: hundreds of people weighing in on a big issue, then attempting to make practical changes with the help of local organisations – and there are groups like us popping up from Cornwall to Glasgow, and Italy and Germany, too. The potential of assemblies is nothing short of revolutionary. It is the potential to change everything.
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Efficiently run food supply chains can positively impact communities and lives across the globe. Real-time tracking supports sustainability, prevents food waste, and ensures compliance with environmental, social and governance (ESG) standards. Communication throughout the supply chain can help producers earn fair compensation for their efforts. Traditional approach to food supply chain management face challenges to efficiency, security and transparency. The consequences can be dire, from food waste to death by contamination. Blockchain technology can provide much-needed transparency, traceability and privacy, as well as co-ordination across disparate parties, enabling greater food access and quality improvements across the global supply chain. Built on a blockchain backend, Silal Fresh adopted a comprehensive traceability solution that utilizes consumer apps, a web-based dashboard, and integration with existing supply chain management systems. This significantly improved identifying and flagging delays in their deliveries, as well as increased satisfaction, trust and brand loyalty. They even added tracking to each piece of produce so that a consumer could pick up a vegetable, scan a QR code, and see that food item's journey. Ultimately, increased transparency and traceability can save lives. With improved traceability, food recalls can happen faster, and the source of contamination can be determined quicker.
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There is a massive battery right under your feet. Unlike a flammable lithium ion battery, though, this one is perfectly stable, free to use, and ripe for sustainable exploitation: the Earth itself. While temperatures above ground fluctuate throughout the year, the ground stays a stable temperature, meaning that it is humming with geothermal energy. "Every building sits on a thermal asset," said Cameron Best, director of business development at Brightcore Energy in New York, which deploys geothermal systems. "I really don't think there's any more efficient or better way to heat and cool our homes." A couple of months ago Eversource Energy commissioned the US's first networked geothermal neighbourhood operated by a utility, in Framingham, Massachusetts. Pipes run down boreholes 600-700ft (about 180-215 metres) deep, where the temperature of the rock is consistently 55F (13C). A mixture of water and propylene glycol ... pumps through the piping, absorbing that geothermal energy. Heat pumps use the liquid to either heat or cool a space. If deployed across the country, these geothermal systems could go a long way in helping decarbonise buildings, which are responsible for about a third of total greenhouse gas emissions in the US. Once a system is in place, buildings can draw heat from water pumped from below their foundations, instead of burning natural gas. The networks ... can be set up almost anywhere.
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Dr. Kate Mulligan is the Senior Director of the Canadian Institute for Social Prescribing (CISP), a new national hub created to support health care providers and social services professionals to connect people to non-clinical supports and community resources. Mulligan ... led one of Canada's first social prescribing projects. "They have a conversation with someone with expertise [like a doctor] to determine a plan, and get support to follow through on something non-clinical that benefits their health. It should be happening systematically, as a regular part of our health system," [said Mulligan]. Someone experiencing food insecurity or an illness like diabetes can be prescribed fresh foods. That could mean a voucher for your local farmers' market, a food box delivery to your home or a credit card that you can spend at the regular grocery store. Social prescribing also means making sure the provided food is culturally appropriate ... thinking about possible connections to include and benefit local farmers. A small community largely inhabited by retirees – lots of people ending up living alone without a strong support network – implemented social prescribing. An older man was diagnosed with depression after his wife died. He kept going for primary care, but really what he was experiencing was unsupported grief. Through social prescribing, he was connected with a fishing rod and a fishing buddy. This is like a $20 intervention. Within a fairly short time, he got off his medication and reconnected with other services too – built friendships, got connected to other community offerings. The health centre started developing their own services, like grief support cooking classes for older grieving widows.
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When you are a child who has been abused by people who are supposed to protect you, how do you feel safe? That question is the heart of Bikers Against Child Abuse International (B.A.C.A.), an organization dedicated to creating "a safer environment for abused children." With specific training and extensive security checks, the frequently big and burly members of B.A.C.A. serve as protectors of chid abuse survivors. They take a photograph with the child, which the child keeps to remind them that they have family to call on. They serve as escorts when kids feel frightened to go somewhere. They show up at court hearings to help kids feel less intimidated. And check out the B.A.C.A creed to see how dedicated these folks are to this work: "I am a Member of Bikers Against Child Abuse. The die has been cast. The decision has been made. I have stepped over the line. I won't look back, let up, slow down, back away, or be still. My past has prepared me, my present makes sense, and my future is secure. I'm finished and done with low living, sight walking, small planning, smooth knees, colorless dreams, tamed visions, mundane talking, cheap giving, and dwarfed goals. I no longer need pre-eminence, prosperity, position, promotions, plaudits, or popularity. I don't have to be right, first, tops, recognized, praised, regarded, or rewarded. I won't give up, shut up, let up, until I have stayed up, stored up, prayed up, paid up, and showed up for all wounded children."
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Trine Krebs is sometimes called "the leek woman," or even Miss Dry-Legume, of Denmark. The 48-year-old has for decades traveled around the country as, in her words, a "food inspirer," proselytizing about all things vegetables. So when, in October 2023, the Danish government published the world's first ever national action plan for shifting towards plant-based diets, Krebs was ecstatic. The Danish government has three main goals: to increase demand for plant-based foods, to develop supply for plant-based foods, and to improve how all the different stakeholders – from scientists to farmers and chefs, food sociologists, and nutrition experts – in this nascent domestic industry are working together. Danish authorities see reducing meat and dairy consumption as key to reaching the Nordic state's goal of cutting carbon emissions by 70 percent before 2030, when compared to 1990. The climate think tank Concito estimates that more than half of Denmark's land is used for farming and that agriculture accounts for about a third of its carbon emissions. Yet a published in 2021 found that the emissions made by producing plant-based foods are roughly half the amount incurred by meat production. Denmark believes ... that the necessary shift toward plant-based eating also offers a massive economic opportunity. If the country were to gain a three percent share of the global plant-based food market, it could create up to 27,000 jobs.
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Can you eat a diet that's good for your health and good for the planet? A new study suggests that it's possible. It found that people who ate mostly minimally processed plant foods such as nuts, beans, fruits, vegetables, whole grains and olive oil, along with modest amounts of meat, fish, eggs and dairy, had lower rates of premature death from heart disease, cancer and other chronic diseases. At the same time, their diets had a smaller environmental footprint because they consisted of foods that were grown using relatively less land and water and that were produced with fewer greenhouse gas emissions. The study ... was inspired by a landmark 2019 report from the EAT-Lancet Commission, which designed a "Planetary Health Diet" capable of sustaining 10 billion people and the planet by 2050. The planetary health diet, in broad strokes, encourages people to eat more plants and whole foods alongside small portions of meat and dairy. People whose eating habits most closely adhered to the planetary health diet were 30 percent less likely to die prematurely compared to people who ate the lowest amounts of foods that form the basis of the planetary health diet. Planetary health eaters had a 10 percent lower risk of dying from cancer, a 14 percent lower likelihood of dying from cardiovascular diseases, a 47 percent reduction in the risk of dying from lung disease, and a 28 percent lower likelihood of dying of Alzheimer's disease and other neurodegenerative disorders.
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The Offline Club, which began life in Amsterdam, offers an oasis of calm and respite from the incessant digital hustle of life lived through the black glass of a smartphone. It nurtures moments of quiet introspection over vapid doomscrolling, and encourages spontaneous conversations with strangers instead of endless keyboard arguments. The concept grew organically from the â€offline getaway' retreats [co-founder Ilya] Kneppelhout set up with pals Valentijn Klok and Jordy van Bennekom. The trio opened their first phone-free hangout in Amsterdam's Cafe Brecht in February this year, and to their astonishment drew 125,000 new Instagram followers in the space of a month. Customers alternate between time to themselves and time to connect. "People don't just pay to get rid of their phones – they're also paying to meet others," says Kneppelhout. "We live in quite an isolated world where we're ever more connected online, but in the physical world, it's hard to meet people. This is a real experience: where else are you going to be in a cafe with 30 others, and read a book or draw? It's quite unique." His hope is that customers will take away lasting habits from their cafe visits. "Big tech companies and the biggest social media companies are really playing with our minds, and with our time and our attention," he says. "I think that's bad: a counter movement is really necessary, and I think it's happening."
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Rhoda Phiri was having a hard time sleeping. She found it difficult to mingle with people in her community and at church. Even basic chores were hard. She was, she says, in a "dark corner." Then one day in 2020, a couple of women knocked on the door of her home in Zambia. The women were with StrongMinds, an international nonprofit that provides support for depression, particularly among women and adolescents. She accepted the women's invitation to join a group therapy program, held under a tree in an area near her home, and as she learned about depression, she recognized the signs in herself. "All the symptoms they were talking about, it's like they were talking about me," Phiri says. "It's like they knew what I was going through." Instead of relying on mental health professionals, StrongMinds offers group therapy facilitated by trained community members – often clients who have completed the treatment themselves, like Phiri. This group therapy model has proven to be an effective way to treat depression. Since the organization launched in 2013, half a million people have gone through the treatment program. Three-quarters of participants screened as being free of depression symptoms two weeks after completing it. "What we've learned in 11 years is that depression treatment can be, what we call, democratized," says StrongMinds founder ... Sean Mayberry. "You can take it out of the hands of doctors and nurses and give it to the community itself."
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