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The US Food and Drug Administration approved Janssen Pharmaceuticals Inc.'s esketamine on Tuesday for treatment-resistant depression; the drug is the chemical cousin of ketamine, the powerful anesthetic that has been used illegally as the club drug Special K. It will be sold as Spravato. It's for patients who have tried at least two other medications without success, and it should be taken with an oral antidepressant. "There has been a longstanding need for additional effective treatments for treatment-resistant depression, a serious and life-threatening condition," Dr. Tiffany Farchione, acting director of the Division of Psychiatry Products at the FDA's Center for Drug Evaluation and Research, said. Spravato is a nasal spray administered by an approved health care provider in a doctor's office or a medical clinic. It may also be self-administered but only under the supervision of a care provider and cannot be taken home. Depending on the severity of the patient's depression, it is given either once a week or once every other week. The drug is rapidly acting, so it starts working faster than other antidepressants, according to Janssen. It works by restoring brain cells in patients with treatment-resistant depression. Currently available treatments for major depression are ineffective in 30% to 40% of patients. The drug was designated as a breakthrough therapy in 2013, a status intended to "expedite the development and review of drugs for serious or life-threatening conditions," the FDA said at the time.
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For the first time, the number of children paralyzed by mutant strains of the polio vaccine are greater than the number of children paralyzed by polio itself. So far in 2017, there have been only six cases of "wild" polio reported anywhere in the world. By "wild," public health officials mean the disease caused by polio virus found naturally in the environment. By contrast, there have been 21 cases of vaccine-derived polio this year. These cases look remarkably similar to regular polio. But laboratory tests show they're caused by remnants of the oral polio vaccine that have gotten loose in the environment, mutated and regained their ability to paralyze unvaccinated children. The oral polio vaccine used throughout most of the developing world contains a form of the virus that has been weakened in the laboratory. But it's still a live virus. (This is a different vaccine than the injectable one used in the U.S. and most developed countries. The injectable vaccine is far more expensive and does not contain live forms of the virus.) WHO is attempting to phase out the use of live oral polio vaccine to eliminate the risk that the active virus in the vaccine could mutate into a form that can harm unvaccinated children. But for now, the live vaccine continues to be the workhorse of the global polio eradication campaign. The killed vaccine doesn't fully block the virus from spreading because a person who is immunized can still carry and spread the polio virus.
Note: Explore an excellent article showing how the media and government are complicit in suppressing vital information on the dangers of excessive vaccines to babies and young children. For more along these lines, see concise summaries of deeply revealing news articles on vaccines from reliable major media sources.
Throughout my career as a psychiatrist, I have found, on a clinical and scientific basis, psychiatric drugs do much more harm than good. My professional website (www.breggin.com) began as an attempt to present my scientific research. At the time that I started my reform efforts in the early 1970s, I was nearly alone among psychiatrists or any other professionals in standing up to the pharmaceutical industry, the electroshock industry, the American Psychiatric Association, the AMA, and other members of what I defined as the "psychopharmaceutical complex." When taken for months or years, all psychiatric drugs can seriously damage the brain, prevent recovery, and ruin the individual's quality of life. The psychiatric model of human suffering has caused untold damage to hundreds of millions of victims of involuntary treatment, psychiatric hospitals, drugs and electroshock. It has also set back civilization by undermining Western traditions of individuality, personal responsibility, and love. It has convinced modern society that emotional suffering is based in so-called biochemical imbalances when in reality it is rooted in a complex combination of human nature, individual experience and choice-making, and societal influences. This flawed biological model ignores all the important realities in human life from the dreadful effects of childhood trauma and adult disappointment and loss to the importance of living by worthwhile principles and ideals.
Note: Learn about Dr. Breggin's key role in stopping lobotomies and much more in this informative interview. For more along these lines, see concise summaries of deeply revealing news articles on Big Pharma corruption from reliable major media sources.
Guardian analysis of water samples from around the United States shows that the type of water testing relied on by the US Environmental Protection Agency (EPA) is so limited in scope that it is probably missing significant levels of PFAS pollutants. The undercount leaves regulators with an incomplete picture of the extent of PFAS contamination and reveals how millions of people may be facing an unknown health risk in their drinking water. The analysis checked water samples from PFAS hot spots around the country with two types of tests: an EPA-developed method that detects 30 types of the approximately 9,000 PFAS compounds, and another that checks for a marker of all PFAS. Seven of the nine samples collected showed higher levels of PFAS in water using the test that identifies markers for PFAS, than levels found when the water was tested using the EPA method – and at concentrations as much as 24 times greater. PFAS ... are often called "forever chemicals" because they don't fully break down, accumulating in the environment. Some are toxic at very low levels and have been linked to cancer, birth defects, kidney disease, liver problems, decreased immunity and other serious health issues. The limitations of the test used by state and federal regulators, which is called the EPA 537 method, virtually guarantees regulators will never have a full picture of contamination levels as industry churns out new compounds much faster than researchers can develop the science to measure them.
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In May, a long-awaited randomized, double-blind, placebo-controlled, Phase 3 clinical trial testing MDMA-assisted therapy for the treatment of PTSD was published in Nature Medicine. The trial was conducted by MAPS Public Benefit Corporation, a for-profit subsidiary launched by the registered non-profit in 2014, with the goal of conducting the necessary research to make MDMA a legally available medicine. "We are a for-profit, but we're wholly owned. We only have one shareholder, and it's a non-profit," says CEO Amy Emerson. While a non-profit is tax exempt and operates for charity, the PBC, like a traditional corporation, pays taxes, operates for profit, and has shareholders and stocks. The results of the Phase 3 clinical trial conducted by MAPS PBC revealed that after receiving a combination of talk therapy and MDMA, 67 percent of participants who received the drug no longer met the diagnostic criteria for PTSD, compared to 32 percent of participants who received the placebo. The trial was recently acknowledged as a "big win for the field" in Science Magazine's annual Breakthrough of the Year awards. "In our three-session model, there's no follow-up medication needed," [MAPS CMO Dr. Corine de Boer] says. After pooling the data of six Phase 2 trials together, de Boer's team found that 57 percent of participants no longer met the criteria for PTSD. At a one-year follow-up during which no MDMA was administered, that number increased to 67 percent.
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The sooner most cancers are discovered, the better the odds they can be successfully treated. Mayo Clinic participated in research on a test that can detect more than 50 cancers. "My dad, he was a healthy guy. He didn't have any known risk factors for cancer," Dr. Julia Feygin said. Feygin lost her 40-year-old father to pancreatic cancer when she was 13. Diagnosed at stage three, he lived for nine more months. "I strongly believe that purpose can be found in everything that happens," Feygin said. She's now part of a team at a Menlo Park, California-based company called GRAIL that's introducing the blood test, called Galleri. She says can it catch hard-to-detect, aggressive and often deadly cancers like pancreatic, ovarian and esophageal. "If cancers can be detected early, we can dramatically improve patient outcomes," Feygin said. Feygin explains that our blood contains a DNA signature. The blood test tracks the DNA a cancer cell sheds. Two tubes of blood are drawn and sent to GRAIL's lab for analysis. "We can find and sequence these tiny bits of tumor-derived DNA in the blood and, based on the patterns we see, we can reveal if there is a signal for cancer present. We can predict with very high accuracy where in the body this cancer signal is coming from," Feygin said. An interventional study that included Mayo Clinic with 6,600 participants returned 29 signals that were followed by a cancer diagnosis. Another study found a less than 1% false positive rate.
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Singapore is looking into an "unusual surge" of 5,324 new infections of COVID-19, the city-state's health ministry said, its highest such figure since the beginning of the pandemic, as beds in intensive care units fill up. Ten new deaths on Wednesday carried the toll to 349, after 3,277 infections the previous day, while the ICU utilisation rate is nearing 80%, despite a population that is 84% fully vaccinated, with 14% receiving booster doses. While nearly 98.7% of the past month's 90,203 cases had no symptoms, or only mild ones, about 0.2% of those had died, and 0.1% each were being monitored closely in intensive care units (ICU) or were critically ill and intubated there.
Note: If the vaccines are effective and Singapore is 84% vaccinated, why are they experiencing the highest surge ever of cases and why are their ICU's 80% full? For more along these lines, see concise summaries of deeply revealing news articles on the coronavirus from reliable major media sources.
Managers and career staff in the Environmental Protection Agency's Office of Chemical Safety and Pollution Prevention tampered with the assessments of dozens of chemicals to make them appear safer, according to four scientists who work at the agency. The whistleblowers, whose jobs involve identifying the potential harms posed by new chemicals, provided ... detailed evidence of pressure within the agency to minimize or remove evidence of potential adverse effects of the chemicals, including neurological effects, birth defects, and cancer. Information about hazards was deleted from agency assessments without informing or seeking the consent of the scientists who authored them. Some of these cases led the EPA to withhold critical information from the public about potentially dangerous chemical exposures. In other cases, the removal of the hazard information or the altering of the scientists' conclusions in reports paved the way for the use of chemicals, which otherwise would not have been allowed on the market. William Irwin, [one] of the four whistleblowers, who has worked at the EPA for over 11 years as a toxicologist, was ... moved out of the office after repeatedly resisting pressure to change his assessments to favor industry. Irwin said that while it had seemed obvious that the pressure stemmed from chemical companies, the science adviser in the office made the point irrefutably clear during an argument over one particular chemical assessment.
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There is clearly a psychedelic renaissance underway. These agents are now debated at medical conferences smirk-free, and my investment-obsessed friends predict a financial "â€shroom-boom". During the 2020 US election ... Measure 109 asked voters in Oregon whether magic mushrooms should be allowed for medical purposes, and Initiative 81 asked Washingtonians about decriminalizing psychedelic plants and fungi. Research is also underway in institutions from Johns Hopkins to Imperial College London. Recently, Health Canada quietly ... allowed four terminally ill patients to take psilocybin under medical supervision. I have also been asked by several patients, at end-of-life, to prescribe a gram of mushrooms or a tablet of lysergic acid diethylamine (which my pharmacy cannot furnish), rather than a "bucket of fentanyl" (which the pharmacy readily can). The Default Mode Network (DMN) ... refers to interconnected brain regions that help us believe we are a distinct self, separate from others and the natural world. This drives self-reliance, but can make us feel isolated. Moreover, as it "matures," we respond in more habitual, predictable, rigid ways. The theory is that DMN overactivity leads to excessive introspection, hypercriticism, obsession, depression, and anxiety. Psychedelics might decrease the tyranny of the DMN, thereby allowing unfamiliar parts of the brain to go on a play-date. We should not throw out the scientific method, but psychedelics could increase the colors in our crayon set.
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Health authorities are investigating the case of a Florida doctor who died from an unusually severe blood disorder 16 days after receiving the Pfizer coronavirus vaccine. Dr. Gregory Michael, a 56-year-old obstetrician and gynecologist in Miami Beach, received the vaccine at Mount Sinai Medical Center on Dec. 18 and died 16 days later from a brain hemorrhage, his wife, Heidi Neckelmann, wrote. Shortly after receiving the vaccine, Dr. Michael developed an extremely serious form of a condition known as acute immune thrombocytopenia, which prevented his blood from clotting properly. About nine million people in the United States have received at least one shot of either the Pfizer or Moderna coronavirus vaccine, the two authorized in the United States. So far, serious problems reported were 29 cases of anaphylaxis, a severe allergic reaction. Dr. Jerry L. Spivak, an expert on blood disorders at Johns Hopkins University, who was not involved in Dr. Michael's care, said that based on Ms. Neckelmann's description, "I think it is a medical certainty that the vaccine was related." "This is going to be very rare," said Dr. Spivak, an emeritus professor of medicine. But he added, "It happened and it could happen again." Dr. Paul Offit, an expert in vaccines and infectious diseases ... said that the measles vaccine and measles itself have been known to cause this same clotting problem, but it is usually transient and not serious. It occurs in about one of every 25,000 measles shots
Note: The supposed experts are claiming the numerous deaths of people within hours to weeks after the vaccine are just coincidental. This article examines these deaths and raises many questions. And why are so few of these being reported? Read about many problems with these vaccines based on reports from reliable sources. For more, see concise summaries of deeply revealing news articles on coronavirus vaccines from reliable major media sources. Then explore the excellent, reliable resources provided in our Coronavirus Information Center.
A third of Americans are showing signs of clinical anxiety or depression, Census Bureau data shows, the most definitive and alarming sign yet of the psychological toll exacted by the coronavirus pandemic. When asked questions normally used to screen patients for mental health problems, 24 percent showed clinically significant symptoms of major depressive disorder and 30 percent showed symptoms of generalized anxiety disorder. The findings suggest a huge jump from before the pandemic. For example, on one question about depressed mood, the percentage reporting such symptoms was double that found in a 2014 national survey. The troubling statistics were released last week in a tranche of data from the Census Bureau. The agency launched an emergency weekly survey of U.S. households at the end of April to measure the pandemic’s effects on employment, housing, finances, education and health. In the most recent data release, 1 million households were contacted between May 7 and 12, and more than 42,000 responded. Buried within that 20-minute survey, U.S. officials included four questions taken nearly word-for-word from a form used by doctors to screen patients for depression and anxiety. Those answers provide a real-time window into the country’s collective mental health after three months of fear, isolation, soaring unemployment and continuing uncertainty. Those results reflect a deepening of existing trends: rising depression, stress and suicide among young adults.
Note: Read also a Washington Post article titled "A massive wave of evictions is coming." For more along these lines, see concise summaries of deeply revealing news articles on the coronavirus and health from reliable major media sources.
At 74, the venture capitalist George Sarlo might not have seemed an obvious candidate for an ayahuasca experience. Mr. Sarlo’s close friend, a doctor, told him about ayahuasca, a psychedelic brew made from the Banisteriopsis caapi vine, native to the Amazon. Used for centuries in sacred healing traditions throughout Central and South America, ayahuasca is now gaining popularity around the world. [It] is mostly illegal in the United States. Notably, ayahuasca’s increasing popularity knows no age limits: many of those now showing interest are squarely in Mr. Sarlo’s own demographic. Mr. Sarlo himself was initially skeptical. Taking ayahuasca would entail a potentially distressing night of hallucinations, and excretions of all kind, especially vomiting. But he still decided to head to Yelapa, a small village in Mexico, and swallow down the bitter brew. Mr. Sarlo said that afterward, something shifted. “It changed my life completely.” He realized that his life had been “absolutely full of miracles,” he said. As Michael Pollan put it, “psychedelics might be wasted on the young.” Mr. Pollan, the author of the recent best seller “How To Change Your Mind,” a history of psychedelics and a chronicle of his own experiences trying them, said ... he was surprised by the number of people he encountered when writing his book in their 70s and 80s expressing interest in trying psychedelics. Though perhaps he shouldn’t have been: as he himself has written, one of the reasons to come to psychedelics later in life is to tangle with one’s own mortality.
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New research finds that individuals with higher optimism tend to live longer and also have greater odds of living 85 years and more. A recent PNAS paper describes how the researchers assessed the link between higher optimism and longer lifespan, with a particular focus on the chances of reaching "exceptional longevity." The team carried out the study because most research on exceptional longevity has tended to focus on the effect of "biomedical factors." More recently, however, scientists have become interested in the role of nonbiological factors. "While research has identified many risk factors for diseases and premature death," says first and corresponding author Lewina O. Lee, Ph.D., "we know relatively less about positive psychosocial factors that can promote healthy aging." She and her colleagues defined optimism as the "general expectation that good things will happen or the belief that the future will be favorable because one can control important outcomes." For the analysis, the team brought together data on 69,744 females ... and 1,429 males. The questionnaires that they completed ... included items on optimism. When the researchers analyzed the data, they found that the females and males with the highest levels of optimism ... lived on average 11–15% longer than those with the lowest levels of optimism. In addition, [those] with the highest levels of optimism had a 50–70% greater likelihood of living until their 85th birthday and beyond.
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Last May, an elderly man was admitted to the Brooklyn branch of Mount Sinai Hospital for abdominal surgery. A blood test revealed that he was infected with a newly discovered germ as deadly as it was mysterious. Doctors swiftly isolated him in the intensive care unit. The germ, a fungus called Candida auris, preys on people with weakened immune systems, and it is quietly spreading across the globe. Recently C. auris reached New York, New Jersey and Illinois, leading the federal Centers for Disease Control and Prevention to add it to a list of germs deemed “urgent threats.” C. auris is so tenacious, in part, because it is impervious to major antifungal medications, making it a new example of one of the world’s most intractable health threats: the rise of drug-resistant infections. For decades, public health experts have warned that the overuse of antibiotics was reducing the effectiveness of drugs that have lengthened life spans by curing bacterial infections once commonly fatal. But lately, there has been an explosion of resistant fungi as well. Yet as the problem grows, it is little understood by the public — in part because the very existence of resistant infections is often cloaked in secrecy. With bacteria and fungi alike, hospitals and local governments are reluctant to disclose outbreaks for fear of being seen as infection hubs. Even the C.D.C., under its agreement with states, is not allowed to make public the location or name of hospitals involved in outbreaks.
Note: For more on this new disease, see this article. For more along these lines, see concise summaries of deeply revealing health news articles from reliable major media sources.
Near Tampa Bay, Florida, I watched airboats move up and down the river banks, spraying massive plumes of weedkiller. The main active ingredient in that mist ... is glyphosate. It is now an ingredient in more than 750 products, including ... Monsanto’s Roundup. This August, the jury in a civil trial found Monsanto, which was acquired [by] Bayer, guilty of causing the cancer of Dewayne Johnson, a school groundskeeper. Roughly 8,700 similar cases against Monsanto are also before the courts. Almonds, carrots, quinoa, soy products, vegetable oil, corn and corn oil, canola seeds used in canola oil, beets and beet sugar, sweet potatoes – these are just some of the foodstuffs which typically contain high levels of glyphosate. Research released in August by the non-profit Environmental Working Group (EWG) found that Cheerios, Quaker Old Fashioned Oats and at least 29 other popular breakfast foods contained what the EWG considers unsafe quantities of the herbicide. The environmental group has been urging public action to get the EPA to revise its outdated standards, which currently fail to protect the public from glyphosate in foods. Levels of glyphosate in the bodies of people in some areas appear to have jumped over 1,300% in the past 20 years. Unlike pharmaceuticals, which have to go through relatively rigorous (if imperfect) testing before being released on the marketplace, the vast majority of chemicals like glyphosate will never be adequately tested for their effects on ecosystems or human beings.
Note: The above article was written by activist Erin Brockovich. For more along these lines, see concise summaries of deeply revealing news articles on food system corruption and health.
In the fall of 1932, the fliers began appearing around Macon County, Ala., promising “colored people” special treatment for “bad blood.” “Free Blood Test; Free Treatment, By County Health Department and Government Doctors,” the black and white signs said. “YOU MAY FEEL WELL AND STILL HAVE BAD BLOOD. COME AND BRING ALL YOUR FAMILY.” Hundreds of men — all black and many of them poor — signed up. What the signs never told them was they would become part of the “Tuskegee Study of Untreated Syphilis in the Negro Male,” a secret experiment conducted by the U.S. Public Health Service to study the progression of the deadly venereal disease — without treatment. The study recruited 600 black men, of which 399 were diagnosed with syphilis and 201 were a control group without the disease. The researchers never obtained informed consent from the men and never told the men with syphilis that they were not being treated but were simply being watched until they died and their bodies examined for ravages of the disease. Initially, when the study began, treatment for syphilis was not effective, often dangerous and fatal. But even after penicillin was discovered and used as a treatment for the disease, the men in the Tuskegee study were not offered the antibiotic. Although originally projected to last six months, the study extended for 40 years. “Local physicians asked to assist with study and not to treat men,” the Centers for Disease Control reported in a timeline of the experiment.
Note: Read more about the Tuskegee study. This is just one of many known cases of humans being used as guinea pigs. For more along these lines, see concise summaries of deeply revealing news articles on science corruption from reliable major media sources.
The 2,190-mile long Appalachian Trail is daunting even to those who have no trouble walking. That hasn't stopped Stacey Kozel. Her paralyzed body hasn't stopped her, either. The 41-year-old ... was always active until lupus stole her muscles and strength. Since her diagnosis at 19, she ... had always managed to get back on her feet - until a flare-up in March 2014. "I walked into a hospital, came out in a wheelchair," recalled Stacey Kozel. Although Kozel was able to walk stiffly with an old pair of braces, they wouldn't help her walk comfortably enough to embrace the outdoors. The chance finally came when she came across the Ottobock C-Brace. The brace functions essentially as the muscles and bones of a leg. The price tag for the technology was steep: $75,000 each. Kozel's doctors and therapists knew that getting these braces covered by insurance would be an uphill climb. When her claim was finally approved after 12 months, she was "in shock." Three days after Kozel got her braces, Joey Pollak, Kozel's orthopedist, got a call saying Kozel was in a 5K race. "To say Stacey is an overachiever is an understatement," said Pollak. What Pollak did not know was an idea forming in Kozel's head. She wanted to show insurance companies how useful the braces can be for those who have lost their mobility. She set her mind on the Appalachian Trail, just two months after she received her braces. Now, with support from her orthopedist, her mother and strangers along the way, she is slowly approaching her destination.
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In one recent study of health care in 11 high-income countries, the nonprofit Commonwealth Fund found that 44% of Americans had out-of-pocket medical expenses that topped $1,000 in the previous year. Just 16% of Germans reported paying that much. The rates were even lower in France, at 10%, and Great Britain, where only 7% reported similar medical expenses. "Many Americans may not understand how affordable health care is for patients in other countries," said Reginald D. Williams II, who oversees international research at the Commonwealth Fund. "Medical debt is a largely U.S. phenomenon. It just doesn't happen in other countries." Germany, like the U.S., has a largely private health care system that relies on private doctors and private insurers. Like Americans, many Germans enroll in a health plan through work, splitting the cost with their employer. But Germany has long done something the U.S. does not: It strictly limits how much patients have to pay out of their own pockets for a trip to the doctor, the hospital or the pharmacy. This regulation occurs through a highly structured system in which insurers negotiate collectively with physician and hospital groups to set prices. American hospitals and other medical providers for decades have fiercely resisted limits on their prices, spending millions to fight government regulation. [Dr. Eckart] Rolshoven's patients pay nothing when they see him. That not only bolsters their health, he said. It helps maintain what Rolshoven called social peace.
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The US Supreme Court let stand an $87 million award against Bayer AG, rejecting the company for the second time in a week as it tries to fend off tens of thousands of claims that its top-selling Roundup weedkiller causes cancer. The justices, making no comment, on Monday left in place a jury's finding in favor of Alva and Alberta Pilliod in a California case. Bayer argued that a federal law precluded the suit and that the $70 million punitive damages award was so large it violated the Constitution. The court last week rejected Bayer's appeal in a case the company was trying to use to scuttle billions of dollars in potential claims. The company's liability could be the full $16 billion it has set aside to resolve the litigation, according to Bloomberg Intelligence analyst Holly Froum. Earlier this month, a federal appeals court ordered the US Environmental Protection Agency to take another look at whether glyphosate - Roundup's active ingredient - is a carcinogen. Studies have linked it to some cancers. The German chemicals giant said it "is fully prepared to manage the litigation risk associated with potential future claims in the US as previously communicated in July 2021, including a voluntary claims program, transition of active ingredients for glyphosate-based products in the US." Bayer inherited the legal mess in 2018 when it acquired Monsanto Co., the herbicide's maker. Bayer has won four of seven Roundup trials so far, with all its losses occurring in California courts. The case is Monsanto v. Pilliod, 21-1272.
Note: Instead of relying on independent science, the EPA used industry studies to determine that glyphosate was safe. For more along these lines, see concise summaries of deeply revealing news articles on corporate corruption and health from reliable major media sources.
When the coronavirus first emerged last year, health officials feared the pandemic would sweep across Africa, killing millions. Although it's still unclear what COVID-19's ultimate toll will be, that catastrophic scenario has yet to materialize in Zimbabwe or much of the continent. Scientists emphasize that obtaining accurate COVID-19 data, particularly in African countries with patchy surveillance, is extremely difficult. But there is something "mysterious" going on in Africa that is puzzling scientists, said Wafaa El-Sadr, chair of global health at Columbia University. "Africa doesn't have the vaccines and the resources to fight COVID-19 that they have in Europe and the U.S., but somehow they seem to be doing better," she said. Fewer than 6% of people in Africa are vaccinated. For months, the WHO has described Africa as "one of the least affected regions in the world" in its weekly pandemic reports. Some researchers say the continent's younger population - the average age is 20 versus about 43 in Western Europe - in addition to their lower rates of urbanization and tendency to spend time outdoors, may have spared it the more lethal effects of the virus so far. Several studies are probing whether there might be other explanations. WHO data show that deaths in Africa make up just 3% of the global total.
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