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Excerpts of Key Health News Stories in Major Media

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When he was just 7 years old, Sacramento native Nate DeFelice was told he had Type 1 diabetes. So when he joined a diabetes research project at Ben-Gurion University [in Israel] two years ago, he hoped it would be a meaningful experience. As it turns out, the project could change his life and those of millions of other diabetics. DeFelice, 27, never dreamed that he would help discover a potential cure for his disease, see the beginning of a Federal Drug Administration-approved clinical trial in the United States, and co-author a scientific paper along with seven other researchers published in October by the National Academy of Sciences. Type 1 diabetes, usually diagnosed in childhood, is caused by a failure of the insulin-producing cells in the pancreas called "islets." They require daily injections of insulin, which helps break down glucose in the blood. When Ben-Gurion University biochemistry Professor Dr. Eli Lewis asked for volunteers to participate in new research on diabetes, DeFelice jumped at the chance. Lewis, DeFelice and the other researchers have focused their investigations on islet transplantation. The Israeli team then opted for a new approach, ... focusing ... on inflammation caused by the transplant itself. Lewis grafted healthy islets into diabetic mice and treated them with an anti-inflammatory drug called alpha-1-antitrypsin, or AAT. Within months, they discovered three encouraging results: AAT enabled the newly grafted islets to survive indefinitely, successfully secreting insulin. The researchers stopped administering AAT and the islets continued to function. The mice's immune systems remained intact and were able to reject additional grafts while the original transplant continued to function.

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What are the pills in your medicine cabinet, and how do you know they're best for you? When drug companies seek approval to market new medicines, they must show the U.S. Food and Drug Administration the results of all the tests they've run on volunteer patients - at first on only a few, then on dozens, and finally on hundreds or sometimes thousands. After winning approval, the companies typically sponsor reports of those tests in medical journal publications, which many doctors often rely on to determine whether to prescribe new drugs for their patients. Now a skeptical team of medical investigators at UCSF has accused the major drug companies of bias by distorting the results of their trials in those publications, making it hard for doctors to judge for themselves the pros and cons of prescribing the new drugs. As a result, the researchers say, patients may sometimes be taking medicines they don't need - or with unwanted side effects - that their doctors have prescribed on the basis of inadequate information. The UCSF team, led by Lisa A. Bero of the medical center's Institute for Health Policy Studies, probed the details of 164 drug trials involving as many as 1,500 patients over a two-year period and then examined reports on those trials that were published in medical journals, as well as those that remained unpublished. "We found really important information from the official trial reports that were either not published at all or that stressed mostly the positive results of trials in the published versions," said Kristin Rising, a physician at the institute who did the major investigation.

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In a sweeping critique ... an expert panel of the National Research Council said the federal government was not doing enough to identify potential health and environmental risks from engineered nanomaterials. Nanomaterials are engineered on the scale of a billionth of a meter, perhaps 1/10,000 the width of a human hair. They are turning up in a range of items including consumer products like toothpaste and tennis rackets and industrial products like degreasers or adhesives. But some experts say they may pose health or environmental risks. For example, researchers in Scotland reported this year that carbon nanotubes may pose the same health risks as asbestos. “Industry wants to run with it,” said Andrew D. Maynard, chief science adviser to the Project on Emerging Nanotechnologies at the Woodrow Wilson Institute, who was the chairman of the panel. But he added, “one of the big barriers at the moment is understanding how to use it safely.” The panel analyzed the risk research strategy of the National Nanotechnology Initiative, the program to coordinate federal efforts in nanotechnology research and development. Its report concluded that the initiative’s strategy “does not present a vision, contain a clear set of goals, have a plan of action for how the goals are to be achieved, or describe mechanisms to review and evaluate funded research and assess whether progress has been achieved.” An informal coalition of environmental and business organizations praised the report, saying that for three years they had been urging the federal government to do more to assess potential health and environmental effects of nanomaterials.

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Vitamin D-binding protein-derived macrophage activating factor (GcMAF) appears to be an effective immunotherapeutic agent in patients with metastatic breast cancer, according to US and Japanese researchers. "Serum vitamin D-binding protein -- known as Gc protein -- is the precursor of the principal macrophage activating factor," lead investigator Dr. Nobuto Yamamoto told Reuters Health. "Treatment of purified Gc protein with beta-galactosidase and sialidase generates GcMAF," he added, "the most potent macrophage activating factor ever discovered, which produces no side effect in humans." Dr. Yamamoto of the Socrates Institute for Therapeutic Immunology, Philadelphia and colleagues note that in vitro studies show that macrophages treated with GcMAF have a highly tumoricidal effect in mammary adenocarcinomas. To investigate whether the approach can be effective in humans, the researchers studied 16 non-anemic breast cancer patients who were given "a minute amount -- 100 nanograms per week -- of GcMAF," Dr. Yamamoto said. The researchers found that after 16 to 22 GcMAF doses, initially elevated nagalase levels, which reflect the tumor burden, fell to those found in healthy controls. Follow-up over 4 years showed that the level remained low and that there was no tumor recurrence, they report in the January 15th issue of The International Journal of Cancer. The findings, the team concludes, clearly demonstrate "the importance of focusing cancer immunotherapy on macrophage activation."

Note: Another article from the National Institutes of Health website covers an experiment with colorectal cancer patients using this amazing discovery. It states that "all colorectal cancer patients exhibited healthy control levels of the serum Nagalase activity, indicating eradication of metastatic tumor cells." Why isn't this getting more major press coverage?

The male [sex] is in danger, with incalculable consequences for both humans and wildlife, startling scientific research from around the world reveals. The research ... shows that a host of common chemicals is feminising males of every class of vertebrate animals, from fish to mammals, including people. Backed by some of the world's leading scientists, who say that it "waves a red flag" for humanity and shows that evolution itself is being disrupted, the report comes out at a particularly sensitive time for ministers. It also follows hard on the heels of new American research which shows that baby boys born to women exposed to widespread chemicals in pregnancy are born with smaller penises and feminised genitals. "This research shows that the basic male tool kit is under threat," says Gwynne Lyons, a former government adviser on the health effects of chemicals, who wrote the report. Wildlife and people have been exposed to more than 100,000 new chemicals in recent years, and the European Commission has admitted that 99 per cent of them are not adequately regulated. There is not even proper safety information on 85 per cent of them. Many have been identified as "endocrine disrupters" – or gender-benders – because they interfere with hormones. These include phthalates, used in food wrapping, cosmetics and baby powders among other applications; flame retardants in furniture and electrical goods; PCBs, a now banned group of substances still widespread in food and the environment; and many pesticides.

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Neuroscientists have shown that they can [create] a “body swapping” illusion that could have a profound effect on a range of therapeutic techniques. At the annual meeting of the Society for Neuroscience last month, Swedish researchers presented evidence that the brain, when tricked by optical and sensory illusions, can quickly adopt any other human form, no matter how different, as its own. “You can see the possibilities, putting a male in a female body, young in old, white in black and vice versa,” said Dr. Henrik Ehrsson of the Karolinska Institute in Stockholm. The technique is simple. A subject stands or sits opposite the scientist, as if engaged in an interview. Both are wearing headsets, with special goggles, the scientist’s containing small film cameras. The goggles are rigged so the subject sees what the scientist sees: to the right and left are the scientist’s arms, and below is the scientist’s body. To add a physical element, the researchers have each person squeeze the other’s hand, as if in a handshake. Now the subject can see and “feel” the new body. In a matter of seconds, the illusion is complete. In a series of studies, using mannequins and stroking both bodies’ bellies simultaneously, the Karolinska researchers have found that men and women say they not only feel they have taken on the new body, but also unconsciously cringe when it is poked or threatened. In previous work, neuroscientists have induced various kinds of out-of-body experiences using similar techniques. The brain is so easily tricked, they say, precisely because it has spent a lifetime in its own body.

Public health groups, consumer advocates and members of Congress blasted the Food and Drug Administration yesterday for failing to act after discovering trace amounts of the industrial chemical melamine in baby formula sold in the United States. "This FDA, this Bush administration, instead of protecting the public health, is protecting industry," said Rep. Rosa DeLauro (D-Conn.), who chairs the Appropriations subcommittee that oversees the FDA budget. "We're talking about babies, about the most vulnerable. This really makes me angry." The FDA found melamine and cyanuric acid, a related chemical, in samples of baby formula made by major U.S. manufacturers. Melamine can cause kidney and bladder stones and, in worst cases, kidney failure and death. If melamine and cyanuric acid combine, they can form round yellow crystals that can also damage kidneys and destroy renal function. Melamine was found in Good Start Supreme Infant Formula With Iron made by Nestle, and cyanuric acid was detected in Enfamil Lipil With Iron infant formula powder made by Mead Johnson. The FDA has been testing hundreds of food products for melamine in the aftermath of a scandal this year involving Chinese infant formula tainted with melamine. Chinese manufacturers deliberately added the chemical to watered-down formula to make it appear to contain higher levels of protein. More than 50,000 Asian infants were hospitalized, and at least four died.

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Cancer researchers have known for years that it was possible in rare cases for some cancers to go away on their own. There were occasional instances of melanomas and kidney cancers that just vanished. And neuroblastoma, a very rare childhood tumor, can go away without treatment. But these were mostly seen as oddities — an unusual pediatric cancer that might not bear on common cancers of adults, a smattering of case reports of spontaneous cures. And since almost every cancer that is detected is treated, it seemed impossible even to ask what would happen if cancers were left alone. Now, though, researchers say they have found a situation in Norway that has let them ask that question about breast cancer. And their new study, to be published Tuesday in The Archives of Internal Medicine, suggests that even invasive cancers may sometimes go away without treatment and in larger numbers than anyone ever believed. Robert M. Kaplan, the chairman of the department of health services at the School of Public Health at the University of California, Los Angeles, [is] persuaded by the analysis. The implications are potentially enormous, Dr. Kaplan said. If the results are replicated, he said, it could eventually be possible for some women to opt for so-called watchful waiting, monitoring a tumor in their breast to see whether it grows. “People have never thought that way about breast cancer,” he added. Dr. Kaplan and his colleague, Dr. Franz Porzsolt, an oncologist at the University of Ulm, said in an editorial that accompanied the study, “If the spontaneous remission hypothesis is credible, it should cause a major re-evaluation in the approach to breast cancer research and treatment.”

Note: For reports from major media sources on many hopeful new developments in the battle against cancer, click here.

California officials recently ordered two "personal genomics" firms to cease and desist operations within the state. The companies eventually were allowed to continue operations - with a few more regulatory conditions - but why did the state demand that they shut down in the first place? Why would a state that regards itself as progressive and high-tech act to censor what we can know about ourselves? Though regulators may shut down unscrupulous firms, the services offered by Navigenics and 23andMe meet the highest standards of accuracy, validity and reliability. The laboratories employed by both companies are fully licensed and trusted by researchers around the world. These companies give individuals the ability to take a "snapshot" of their DNA. The state objected, determining that doctors are gatekeepers of the human body, and Californians need a prescription to access their genetic blueprint. Doctors have a powerful lobby in Sacramento, and these technologies directly threaten their profits. Personal genomics aims to empower the individual, not line the pockets of an elite medical establishment. This establishment believes that individuals cannot be trusted with their own genetic information. The genome is vast, complicated and poorly understood, the argument goes, and therefore customers could be inundated with raw information of little or no practical use. Forbidding us from looking at our genes because we don't yet understand them, however, is contrary to science, innovation and human nature.

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The Food and Drug Administration ignored scientific evidence and used flawed methods when it determined that a chemical widely used in baby bottles and in the lining of cans is not harmful, a scientific advisory panel has found. In a highly critical report ... the panel of scientists from government and academia said the FDA did not take into consideration scores of studies that have linked bisphenol A (BPA) to prostate cancer, diabetes and other health problems in animals when it completed a draft risk assessment of the chemical last month. The panel said the FDA didn't use enough infant formula samples and didn't adequately account for variations among the samples. Taking those studies into consideration, the panel concluded, the FDA's margin of safety is "inadequate". The panel is part of the Science Board, a committee of advisers to the FDA commissioner, and was set up to review the FDA's risk assessment of BPA. Many of the studies that the panel said the FDA ignored were reviewed by the National Toxicology Program, which concluded in September that it had "some concern" that BPA can affect brain and behavioral development in infants and small children. Officials at FDA, which regulates the chemical's use in plastic food containers, bottles, tableware and the plastic linings of food cans, accepted some of the criticism in the report. "FDA agrees that due to the uncertainties raised in some studies relating to the potential effects of low doses of bisphenol-A that additional research would be valuable," said spokeswoman Judy Leon. The agency has commissioned new research on BPA.

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After a century of declines, the U.S. infant mortality rate barely budged between 2000 and 2005, causing the United States to slip further behind other developed countries despite spending more on healthcare, according to a report released Wednesday. The rate was 6.86 infant deaths per 1,000 live births in 2005, virtually unchanged from 6.89 in 2000. In 1900, the rate was 100 deaths per 1,000 live births. The United States dropped to 29th in the world in infant mortality in 2004, the latest year for which data are available from all countries, tying with Poland and Slovakia. The year before, it was 27th. In 1960, it was 12th. The report from the Centers for Disease Control and Prevention attributed the leveling off in mortality to a 9% increase in premature births over the same period and to stalled progress in saving the earliest preterm infants. Premature birth and low birth weight are by far the biggest causes of infant death. Infant mortality rates vary by race and ethnicity, from a high of 13.63 per 1,000 births for African American women to a low of 4.42 for Cuban Americans, according to the CDC report. Differences in socioeconomic status and access to medical care did not entirely explain the gap, the report said. Premature births are increasing, possibly tied to rising rates of obesity, diabetes and hypertension. What those conditions have in common is that they are preventable, and that ... is where the United States falls behind other developed countries.

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A retired medical supply manufacturer who considers bisphenol A to be "perfectly safe" gave $5 million to the research center headed by the chairman of a Food and Drug Administration panel about to rule on the chemical's safety. The July donation from Charles Gelman is nearly 50 times the annual budget of the University of Michigan Risk Science Center, where Martin Philbert is founder and co-director. Philbert did not disclose the donation to the FDA, and agency officials learned of it when reporters asked about it. Gelman said he considers the chemical, which is used to make baby bottles and aluminum can liners, to be safe. He said he had made his views clear to Philbert in several conversations. Philbert denied that. Philbert's committee is expected to release its opinion this month. The decision of Philbert's committee is expected to have huge implications on the regulation and sale of the chemical in items such as baby bottles, reusable food containers and plastic wraps. Since the late 1990s, studies have linked bisphenol A to cancer, heart disease, obesity, reproductive failures and hyperactivity in laboratory animals. Gelman, a retired manufacturer of syringes and medical filtration devices, has fought against government regulation of pollutants for years. He is an anti-regulation activist and an outspoken supporter of organizations such as JunkScience.com, the Cato Institute and the Competitive Enterprise Institute that attack the credibility of government and academic scientists on such topics as global warming and hazardous chemicals.

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Scientists on Thursday warned US legislators of the risks of brain cancer from cell phone use, highlighting the potential risk for children who use mobile phones. "We urgently need more research," said David Carpenter, director of the Institute of Health and Environment at the University of Albany, in testimony before the House Subcommittee on Domestic Policy. "We must not repeat the situation we had with the relationship between smoking and lung cancer," Carpenter said. Ronald Herberman, director of the University of Pittsburgh Cancer Institute, said that most studies "claiming that there is no link between cell phones and brain tumors are outdated, had methodological concerns and did not include sufficient numbers of long-term cell phone users." Many studies denying a link "defined regular cell phones as 'once a week,'" added Herberman. "I cannot tell this committee that cell phones are definitely dangerous. But, I certainly cannot tell you that they are safe," he said. Carpenter and Herberman both told the committee the brain cancer risk from cell phone use is far greater for children than for adults. Herberman held up a model for lawmakers showing how radiation from a cell phone penetrates far deeper into the brain of a 5-year-old than that of an adult. "Every child is using cell phones all of the time, and there are three billion cell phone users in the world," said Herberman. He added that, like the messages that warn of health risks on cigarette packs, cell phones "need a precautionary message."

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Britain's first human-animal hybrid embryos have been created, forming a crucial first step, scientists believe, towards a supply of stem cells that could be used to investigate debilitating and so far untreatable conditions such as Alzheimer's disease, Parkinson's and motor neurone disease. Lyle Armstrong, who led the work, gained permission in January from the Human Fertilisation and Embryology Authority (HFEA) to create the embryos, known as "cytoplasmic hybrids". His team at Newcastle University produced the embryos by inserting human DNA from a skin cell into a hollowed-out cow egg. An electric shock then induced the hybrid embryo to grow. The embryo, 99.9% human and 0.1% other animal, grew for three days, until it had 32 cells. Eventually, scientists hope to grow such embryos for six days, and then extract stem cells from them. The researchers insisted the embryos would never be implanted into a woman and that the only reason they used cow eggs was due to the scarcity of human eggs. Cardinal Keith O'Brien used his Easter sermon to denounce what he called experiments of "Frankenstein proportion" and called the bill a "monstrous attack on human rights, human dignity and human life". Catholics object to the idea of putting human and animal DNA in the same entity and to the notion of creating what they regard as a life for the purposes of research, a life that will then be destroyed.

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Children and teenagers are five times more likely to get brain cancer if they use mobile phones, startling new research indicates. The study, experts say, raises fears that today's young people may suffer an "epidemic" of the disease in later life. At least nine out of 10 British 16-year-olds have their own handset, as do more than 40 per cent of primary schoolchildren. Yet investigating dangers to the young has been omitted from a massive Ł3.1m British investigation of the risks of cancer from using mobile phones, launched this year, even though the official Mobile Telecommunications and Health Research (MTHR) Programme – which is conducting it – admits that the issue is of the "highest priority". Despite recommendations of an official report that the use of mobiles by children should be "minimised", the Government has done almost nothing to discourage it. Last week the European Parliament voted by 522 to 16 to urge ministers across Europe to bring in stricter limits for exposure to radiation from mobile and cordless phones, Wi-fi and other devices, partly because children are especially vulnerable to them. They are more at risk because their brains and nervous systems are still developing and because – since their heads are smaller and their skulls are thinner – the radiation penetrates deeper into their brains. David Carpenter, dean of the School of Public Health at the State University of New York said: "Children are spending significant time on mobile phones. We may be facing a public health crisis in an epidemic of brain cancers as a result of mobile phone use."

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Two vaccines against cervical cancer are being widely used without sufficient evidence about whether they are worth their high cost or even whether they will effectively stop women from getting the disease, two articles in this week’s New England Journal of Medicine conclude. Both vaccines target the human papillomavirus, a common sexually transmitted virus that usually causes no symptoms and is cleared by the immune system, but which can in very rare cases become chronic and cause cervical cancer. The two vaccines, Gardasil by Merck Sharp & Dohme and Cervarix by GlaxoSmithKline, target two strains of the virus that together cause an estimated 70 percent of cervical cancers. “Despite great expectations and promising results of clinical trials, we still lack sufficient evidence of an effective vaccine against cervical cancer,” Dr. Charlotte J. Haug ... wrote in an editorial in Thursday’s issue of The New England Journal. “With so many essential questions still unanswered, there is good reason to be cautious.” The vaccines have been studied for a relatively short period — both were licensed in 2006 and have been studied in clinical trials for at most six and a half years. Researchers have not yet demonstrated how long the immunity will last, or whether eliminating some strains of cancer-causing virus will decrease the body’s natural immunity to other strains. Because cervical cancer develops only after years of chronic infection with HPV, Dr. Haug said there was not yet absolute proof that protection against these two strains of the virus would ultimately reduce rates of cervical cancer.

The first large study in humans of a chemical widely used in everyday plastics has found that people with higher levels of bisphenol A had higher rates of heart disease, diabetes and liver abnormalities. The research, published ... in the Journal of the American Medical Association by a team of British and American scientists, compared the health status of 1,455 men and women with the levels of the chemical, known as BPA, in their urine. The researchers divided the subjects into four statistical groupings according to their BPA levels and found that those in the quartile with the highest concentrations were nearly three times as likely to have cardiovascular disease than those with the lowest levels, and 2.4 times as likely to have diabetes. Higher BPA levels were also associated with abnormal concentrations of three liver enzymes. "This is the nail in the coffin," Frederick vom Saal, a reproductive scientist at the University of Missouri at Columbia and one of the first to document evidence of health problems in rodents exposed to low doses of BPA. "This is a huge deal." More than 100 studies have linked BPA exposure to health effects in animals. The FDA maintains that BPA is safe largely on the basis of two studies funded by the chemical industry, a fact that was repeatedly cited at yesterday's forum. "We're concerned that the FDA is basing its conclusion on two studies while downplaying the results of hundreds of other studies," said Amber Wise of the Union of Concerned Scientists. "This appears to be a case of cherry-picking data with potentially high cost to human health."

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Food and milk from the offspring of cloned animals may have entered the U.S. food supply, the U.S. government said on Tuesday, but [then claimed] it would be impossible to know because there is no difference between cloned and conventional products. The U.S. Food and Drug Administration said in January [that] meat and milk from cloned cattle, swine and goats and their offspring were as safe as products from traditional animals. Before then, farmers and ranchers had followed a voluntary moratorium on the sale of clones and their offspring. While the FDA evaluated the safety of food from clones and their offspring, the U.S. Agriculture Department was in charge of managing the transition of these animals into the food supply. "It is theoretically possible" offspring from clones are in the food supply, said Siobhan DeLancey, an FDA spokeswoman. Cloning animals involves taking the nuclei of cells from adults and fusing them into egg cells that are implanted into a surrogate mother. There are an estimated 600 cloned animals in the United States. Critics contend not enough is known about the technology to ensure it is safe, and they also say the FDA needs to address concerns over animal cruelty and ethical issues. "It worries me that this technology is out of control in so many ways," said Charles Margulis, a spokesman with the Center for Environmental Health.

Note: For a revealing summary of the health risks associated with genetically modified foods, click here.

Scientists are exploring the use of psychedelic drugs such as LSD to treat a range of ailments from depression to cluster headaches and obsessive compulsive disorder. The first clinical trial using LSD since the 1970s began in Switzerland in June. It aims to use "psychedelic psychotherapy" to help patients with terminal illnesses come to terms with their imminent mortality and so improve their quality of life. Another psychedelic substance, psilocybin, has shown promising results in trials for treating symptoms of terminal cancer patients. In the Swiss trial eight subjects will receive a dose of 200 microgrammes of LSD. This is enough to induce a powerful psychedelic experience. A further four subjects will receive a dose of 20 microgrammes. Every participant will know they have received some LSD, but neither the subjects nor the researchers observing them will know for certain who received the full dose. During the course of therapy researchers will assess the patients' anxiety levels, quality of life and pain levels. Before hallucinogenic drugs became popular with the counter culture, they were at the forefront of brain science. They were used to help scientists understand the nature of consciousness and how the brain works and as treatments for a range of conditions. Dr Rick Doblin is president of the Multidisciplinary Association for Psychedelic Studies (MAPS) in California, a nonprofit organisation which funds clinical studies into psychedelic drugs, including the Swiss LSD trial. "These drugs, these experiences are not for the mystic who wants to sit on the mountain top and meditate. They are not for the counter-culture rebel. They are for everybody," he said.

Sandra Levy wants to do everything she can to safeguard the health of her 11-year-old daughter -- and that, of course, includes cancer prevention. She has had her child inoculated with one shot of Gardasil, the human papilloma virus vaccine that may prevent cervical cancer. But now, she says, she has serious reservations about going ahead with the next two injections of the course. Though most medical organizations strongly advocate using the HPV vaccine, some doctors and parents, like Levy, are asking whether the vaccine's benefits really outweigh its costs. A report released in June stirred up more doubts. Although cause and effect were not proved, the report listed serious events -- such as seizures, spontaneous abortions and even deaths -- among teens, preteens and young women who had earlier had Gardasil shots. [The] analysis, released June 30 by the Washington, D.C.-based public interest group Judicial Watch, [has] raised [these] red flags. Judicial Watch obtained records from the FDA's Vaccine Adverse Event Reporting System (VAERS), a voluntary system used by doctors, patients and drug companies to report side effects with vaccines to the federal agency. The report revealed that since the vaccine's 2006 approval, when girls began getting it, nearly 9,000 had bad health events after receiving Gardasil. The incidents included 10 miscarriages, 78 severe outbreaks of genital warts and six cases of Guillain-Barré syndrome, an autoimmune disorder that can result in paralysis. There were also 18 reported deaths.

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Important Note: Explore our full index to revealing excerpts of key major media news stories on several dozen engaging topics. And don't miss amazing excerpts from 20 of the most revealing news articles ever published.