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Cancer researchers have known for years that it was possible in rare cases for some cancers to go away on their own. There were occasional instances of melanomas and kidney cancers that just vanished. And neuroblastoma, a very rare childhood tumor, can go away without treatment. But these were mostly seen as oddities — an unusual pediatric cancer that might not bear on common cancers of adults, a smattering of case reports of spontaneous cures. And since almost every cancer that is detected is treated, it seemed impossible even to ask what would happen if cancers were left alone. Now, though, researchers say they have found a situation in Norway that has let them ask that question about breast cancer. And their new study, to be published Tuesday in The Archives of Internal Medicine, suggests that even invasive cancers may sometimes go away without treatment and in larger numbers than anyone ever believed. Robert M. Kaplan, the chairman of the department of health services at the School of Public Health at the University of California, Los Angeles, [is] persuaded by the analysis. The implications are potentially enormous, Dr. Kaplan said. If the results are replicated, he said, it could eventually be possible for some women to opt for so-called watchful waiting, monitoring a tumor in their breast to see whether it grows. “People have never thought that way about breast cancer,” he added. Dr. Kaplan and his colleague, Dr. Franz Porzsolt, an oncologist at the University of Ulm, said in an editorial that accompanied the study, “If the spontaneous remission hypothesis is credible, it should cause a major re-evaluation in the approach to breast cancer research and treatment.”
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California officials recently ordered two "personal genomics" firms to cease and desist operations within the state. The companies eventually were allowed to continue operations - with a few more regulatory conditions - but why did the state demand that they shut down in the first place? Why would a state that regards itself as progressive and high-tech act to censor what we can know about ourselves? Though regulators may shut down unscrupulous firms, the services offered by Navigenics and 23andMe meet the highest standards of accuracy, validity and reliability. The laboratories employed by both companies are fully licensed and trusted by researchers around the world. These companies give individuals the ability to take a "snapshot" of their DNA. The state objected, determining that doctors are gatekeepers of the human body, and Californians need a prescription to access their genetic blueprint. Doctors have a powerful lobby in Sacramento, and these technologies directly threaten their profits. Personal genomics aims to empower the individual, not line the pockets of an elite medical establishment. This establishment believes that individuals cannot be trusted with their own genetic information. The genome is vast, complicated and poorly understood, the argument goes, and therefore customers could be inundated with raw information of little or no practical use. Forbidding us from looking at our genes because we don't yet understand them, however, is contrary to science, innovation and human nature.
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The Food and Drug Administration ignored scientific evidence and used flawed methods when it determined that a chemical widely used in baby bottles and in the lining of cans is not harmful, a scientific advisory panel has found. In a highly critical report ... the panel of scientists from government and academia said the FDA did not take into consideration scores of studies that have linked bisphenol A (BPA) to prostate cancer, diabetes and other health problems in animals when it completed a draft risk assessment of the chemical last month. The panel said the FDA didn't use enough infant formula samples and didn't adequately account for variations among the samples. Taking those studies into consideration, the panel concluded, the FDA's margin of safety is "inadequate". The panel is part of the Science Board, a committee of advisers to the FDA commissioner, and was set up to review the FDA's risk assessment of BPA. Many of the studies that the panel said the FDA ignored were reviewed by the National Toxicology Program, which concluded in September that it had "some concern" that BPA can affect brain and behavioral development in infants and small children. Officials at FDA, which regulates the chemical's use in plastic food containers, bottles, tableware and the plastic linings of food cans, accepted some of the criticism in the report. "FDA agrees that due to the uncertainties raised in some studies relating to the potential effects of low doses of bisphenol-A that additional research would be valuable," said spokeswoman Judy Leon. The agency has commissioned new research on BPA.
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After a century of declines, the U.S. infant mortality rate barely budged between 2000 and 2005, causing the United States to slip further behind other developed countries despite spending more on healthcare, according to a report released Wednesday. The rate was 6.86 infant deaths per 1,000 live births in 2005, virtually unchanged from 6.89 in 2000. In 1900, the rate was 100 deaths per 1,000 live births. The United States dropped to 29th in the world in infant mortality in 2004, the latest year for which data are available from all countries, tying with Poland and Slovakia. The year before, it was 27th. In 1960, it was 12th. The report from the Centers for Disease Control and Prevention attributed the leveling off in mortality to a 9% increase in premature births over the same period and to stalled progress in saving the earliest preterm infants. Premature birth and low birth weight are by far the biggest causes of infant death. Infant mortality rates vary by race and ethnicity, from a high of 13.63 per 1,000 births for African American women to a low of 4.42 for Cuban Americans, according to the CDC report. Differences in socioeconomic status and access to medical care did not entirely explain the gap, the report said. Premature births are increasing, possibly tied to rising rates of obesity, diabetes and hypertension. What those conditions have in common is that they are preventable, and that ... is where the United States falls behind other developed countries.
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A retired medical supply manufacturer who considers bisphenol A to be "perfectly safe" gave $5 million to the research center headed by the chairman of a Food and Drug Administration panel about to rule on the chemical's safety. The July donation from Charles Gelman is nearly 50 times the annual budget of the University of Michigan Risk Science Center, where Martin Philbert is founder and co-director. Philbert did not disclose the donation to the FDA, and agency officials learned of it when reporters asked about it. Gelman said he considers the chemical, which is used to make baby bottles and aluminum can liners, to be safe. He said he had made his views clear to Philbert in several conversations. Philbert denied that. Philbert's committee is expected to release its opinion this month. The decision of Philbert's committee is expected to have huge implications on the regulation and sale of the chemical in items such as baby bottles, reusable food containers and plastic wraps. Since the late 1990s, studies have linked bisphenol A to cancer, heart disease, obesity, reproductive failures and hyperactivity in laboratory animals. Gelman, a retired manufacturer of syringes and medical filtration devices, has fought against government regulation of pollutants for years. He is an anti-regulation activist and an outspoken supporter of organizations such as JunkScience.com, the Cato Institute and the Competitive Enterprise Institute that attack the credibility of government and academic scientists on such topics as global warming and hazardous chemicals.
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Scientists on Thursday warned US legislators of the risks of brain cancer from cell phone use, highlighting the potential risk for children who use mobile phones. "We urgently need more research," said David Carpenter, director of the Institute of Health and Environment at the University of Albany, in testimony before the House Subcommittee on Domestic Policy. "We must not repeat the situation we had with the relationship between smoking and lung cancer," Carpenter said. Ronald Herberman, director of the University of Pittsburgh Cancer Institute, said that most studies "claiming that there is no link between cell phones and brain tumors are outdated, had methodological concerns and did not include sufficient numbers of long-term cell phone users." Many studies denying a link "defined regular cell phones as 'once a week,'" added Herberman. "I cannot tell this committee that cell phones are definitely dangerous. But, I certainly cannot tell you that they are safe," he said. Carpenter and Herberman both told the committee the brain cancer risk from cell phone use is far greater for children than for adults. Herberman held up a model for lawmakers showing how radiation from a cell phone penetrates far deeper into the brain of a 5-year-old than that of an adult. "Every child is using cell phones all of the time, and there are three billion cell phone users in the world," said Herberman. He added that, like the messages that warn of health risks on cigarette packs, cell phones "need a precautionary message."
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Britain's first human-animal hybrid embryos have been created, forming a crucial first step, scientists believe, towards a supply of stem cells that could be used to investigate debilitating and so far untreatable conditions such as Alzheimer's disease, Parkinson's and motor neurone disease. Lyle Armstrong, who led the work, gained permission in January from the Human Fertilisation and Embryology Authority (HFEA) to create the embryos, known as "cytoplasmic hybrids". His team at Newcastle University produced the embryos by inserting human DNA from a skin cell into a hollowed-out cow egg. An electric shock then induced the hybrid embryo to grow. The embryo, 99.9% human and 0.1% other animal, grew for three days, until it had 32 cells. Eventually, scientists hope to grow such embryos for six days, and then extract stem cells from them. The researchers insisted the embryos would never be implanted into a woman and that the only reason they used cow eggs was due to the scarcity of human eggs. Cardinal Keith O'Brien used his Easter sermon to denounce what he called experiments of "Frankenstein proportion" and called the bill a "monstrous attack on human rights, human dignity and human life". Catholics object to the idea of putting human and animal DNA in the same entity and to the notion of creating what they regard as a life for the purposes of research, a life that will then be destroyed.
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Children and teenagers are five times more likely to get brain cancer if they use mobile phones, startling new research indicates. The study, experts say, raises fears that today's young people may suffer an "epidemic" of the disease in later life. At least nine out of 10 British 16-year-olds have their own handset, as do more than 40 per cent of primary schoolchildren. Yet investigating dangers to the young has been omitted from a massive Ł3.1m British investigation of the risks of cancer from using mobile phones, launched this year, even though the official Mobile Telecommunications and Health Research (MTHR) Programme – which is conducting it – admits that the issue is of the "highest priority". Despite recommendations of an official report that the use of mobiles by children should be "minimised", the Government has done almost nothing to discourage it. Last week the European Parliament voted by 522 to 16 to urge ministers across Europe to bring in stricter limits for exposure to radiation from mobile and cordless phones, Wi-fi and other devices, partly because children are especially vulnerable to them. They are more at risk because their brains and nervous systems are still developing and because – since their heads are smaller and their skulls are thinner – the radiation penetrates deeper into their brains. David Carpenter, dean of the School of Public Health at the State University of New York said: "Children are spending significant time on mobile phones. We may be facing a public health crisis in an epidemic of brain cancers as a result of mobile phone use."
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Two vaccines against cervical cancer are being widely used without sufficient evidence about whether they are worth their high cost or even whether they will effectively stop women from getting the disease, two articles in this week’s New England Journal of Medicine conclude. Both vaccines target the human papillomavirus, a common sexually transmitted virus that usually causes no symptoms and is cleared by the immune system, but which can in very rare cases become chronic and cause cervical cancer. The two vaccines, Gardasil by Merck Sharp & Dohme and Cervarix by GlaxoSmithKline, target two strains of the virus that together cause an estimated 70 percent of cervical cancers. “Despite great expectations and promising results of clinical trials, we still lack sufficient evidence of an effective vaccine against cervical cancer,” Dr. Charlotte J. Haug ... wrote in an editorial in Thursday’s issue of The New England Journal. “With so many essential questions still unanswered, there is good reason to be cautious.” The vaccines have been studied for a relatively short period — both were licensed in 2006 and have been studied in clinical trials for at most six and a half years. Researchers have not yet demonstrated how long the immunity will last, or whether eliminating some strains of cancer-causing virus will decrease the body’s natural immunity to other strains. Because cervical cancer develops only after years of chronic infection with HPV, Dr. Haug said there was not yet absolute proof that protection against these two strains of the virus would ultimately reduce rates of cervical cancer.
The first large study in humans of a chemical widely used in everyday plastics has found that people with higher levels of bisphenol A had higher rates of heart disease, diabetes and liver abnormalities. The research, published ... in the Journal of the American Medical Association by a team of British and American scientists, compared the health status of 1,455 men and women with the levels of the chemical, known as BPA, in their urine. The researchers divided the subjects into four statistical groupings according to their BPA levels and found that those in the quartile with the highest concentrations were nearly three times as likely to have cardiovascular disease than those with the lowest levels, and 2.4 times as likely to have diabetes. Higher BPA levels were also associated with abnormal concentrations of three liver enzymes. "This is the nail in the coffin," Frederick vom Saal, a reproductive scientist at the University of Missouri at Columbia and one of the first to document evidence of health problems in rodents exposed to low doses of BPA. "This is a huge deal." More than 100 studies have linked BPA exposure to health effects in animals. The FDA maintains that BPA is safe largely on the basis of two studies funded by the chemical industry, a fact that was repeatedly cited at yesterday's forum. "We're concerned that the FDA is basing its conclusion on two studies while downplaying the results of hundreds of other studies," said Amber Wise of the Union of Concerned Scientists. "This appears to be a case of cherry-picking data with potentially high cost to human health."
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Food and milk from the offspring of cloned animals may have entered the U.S. food supply, the U.S. government said on Tuesday, but [then claimed] it would be impossible to know because there is no difference between cloned and conventional products. The U.S. Food and Drug Administration said in January [that] meat and milk from cloned cattle, swine and goats and their offspring were as safe as products from traditional animals. Before then, farmers and ranchers had followed a voluntary moratorium on the sale of clones and their offspring. While the FDA evaluated the safety of food from clones and their offspring, the U.S. Agriculture Department was in charge of managing the transition of these animals into the food supply. "It is theoretically possible" offspring from clones are in the food supply, said Siobhan DeLancey, an FDA spokeswoman. Cloning animals involves taking the nuclei of cells from adults and fusing them into egg cells that are implanted into a surrogate mother. There are an estimated 600 cloned animals in the United States. Critics contend not enough is known about the technology to ensure it is safe, and they also say the FDA needs to address concerns over animal cruelty and ethical issues. "It worries me that this technology is out of control in so many ways," said Charles Margulis, a spokesman with the Center for Environmental Health.
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Scientists are exploring the use of psychedelic drugs such as LSD to treat a range of ailments from depression to cluster headaches and obsessive compulsive disorder. The first clinical trial using LSD since the 1970s began in Switzerland in June. It aims to use "psychedelic psychotherapy" to help patients with terminal illnesses come to terms with their imminent mortality and so improve their quality of life. Another psychedelic substance, psilocybin, has shown promising results in trials for treating symptoms of terminal cancer patients. In the Swiss trial eight subjects will receive a dose of 200 microgrammes of LSD. This is enough to induce a powerful psychedelic experience. A further four subjects will receive a dose of 20 microgrammes. Every participant will know they have received some LSD, but neither the subjects nor the researchers observing them will know for certain who received the full dose. During the course of therapy researchers will assess the patients' anxiety levels, quality of life and pain levels. Before hallucinogenic drugs became popular with the counter culture, they were at the forefront of brain science. They were used to help scientists understand the nature of consciousness and how the brain works and as treatments for a range of conditions. Dr Rick Doblin is president of the Multidisciplinary Association for Psychedelic Studies (MAPS) in California, a nonprofit organisation which funds clinical studies into psychedelic drugs, including the Swiss LSD trial. "These drugs, these experiences are not for the mystic who wants to sit on the mountain top and meditate. They are not for the counter-culture rebel. They are for everybody," he said.
Sandra Levy wants to do everything she can to safeguard the health of her 11-year-old daughter -- and that, of course, includes cancer prevention. She has had her child inoculated with one shot of Gardasil, the human papilloma virus vaccine that may prevent cervical cancer. But now, she says, she has serious reservations about going ahead with the next two injections of the course. Though most medical organizations strongly advocate using the HPV vaccine, some doctors and parents, like Levy, are asking whether the vaccine's benefits really outweigh its costs. A report released in June stirred up more doubts. Although cause and effect were not proved, the report listed serious events -- such as seizures, spontaneous abortions and even deaths -- among teens, preteens and young women who had earlier had Gardasil shots. [The] analysis, released June 30 by the Washington, D.C.-based public interest group Judicial Watch, [has] raised [these] red flags. Judicial Watch obtained records from the FDA's Vaccine Adverse Event Reporting System (VAERS), a voluntary system used by doctors, patients and drug companies to report side effects with vaccines to the federal agency. The report revealed that since the vaccine's 2006 approval, when girls began getting it, nearly 9,000 had bad health events after receiving Gardasil. The incidents included 10 miscarriages, 78 severe outbreaks of genital warts and six cases of Guillain-Barré syndrome, an autoimmune disorder that can result in paralysis. There were also 18 reported deaths.
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Scientists have stopped the ageing process in an entire organ for the first time, a study released today says. Researchers at the Albert Einstein College of Medicine ... also say the older organs function as well as they did when the host animal was younger. The researchers, led by Associate Professor Ana Maria Cuervo, blocked the ageing process in mice livers by stopping the build-up of harmful proteins inside the organ's cells. As people age their cells become less efficient at getting rid of damaged protein resulting in a build-up of toxic material that is especially pronounced in Alzheimer's, Parkinson's and other neurodegenerative disorders. The researchers say the findings suggest that therapies for boosting protein clearance might help stave off some of the declines in function that accompanies old age. In experiments, livers in genetically modified mice 22 to 26 months old ... cleaned blood as efficiently as those in animals a quarter their age. The benefits of restoring the cleaning mechanisms found inside all cells could extend far beyond a single organ, says Cuervo. "Our findings are particularly relevant for neurodegenerative disorders such as Parkinson's and Alzheimer's," she says. "Many of these diseases are due to 'misbehaving' or damaged proteins that accumulate in neurons. By preventing this decline in protein clearance, we may be able to keep these people free of symptoms for a longer time." If the body's ability to dispose of cell debris within the cell were enhanced across a wider range of tissues, she says, it could extend life as well.
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Health and life insurance companies have access to a powerful new tool for evaluating whether to cover individual consumers: a health "credit report" drawn from databases containing prescription drug records on more than 200 million Americans. Collecting and analyzing personal health information in commercial databases is a fledgling industry, but one poised to take off as the nation enters the age of electronic medical records. Some insurers have already begun testing systems that tap into not only prescription drug information, but also data about patients held by clinical and pathological laboratories. Privacy and consumer advocates fear [the trend] it is taking place largely outside the scrutiny of federal health regulators and lawmakers. The practice also illustrates how electronic data gathered for one purpose can be used and marketed for another -- often without consumers' knowledge, privacy advocates say. And they argue that although consumers sign consent forms, they effectively have to authorize the data release if they want insurance. "As health care moves into the digital age, there are more and more companies holding vast amounts of patients' health information," said Joy Pritts, research professor at Georgetown University's Health Policy Institute. "Most people don't even know these [companies] exist. Unfortunately the federal health privacy rule does not cover many of them." Tim Sparapani, senior legislative counsel at the American Civil Liberties Union, said, "We've got to stop these practices before the marketplace is fully developed and patients lose all control over their medical information."
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The next time you make some microwave popcorn or cook a frozen pizza, consider this: The packaging of many of these products contains a chemical that the Environmental Protection Agency considers potentially carcinogenic and wants businesses to voluntarily stop using by 2015. Studies show that this chemical -- perfluorooctanoic acid, or PFOA -- is present in 98% of Americans' blood and 100% of newborns. It doesn't break down and thus accumulates in the system over time. PFOA ... is used to make Teflon pans, Gore-Tex clothing and to prevent food from sticking to paper packaging. The industry says that while the EPA's carcinogen concerns are based on animal tests, there's no evidence that PFOA is harmful to humans. Public-health advocates counter that the industry is being disingenuous. "There's never been a chemical found that affects animals but has no effect on humans," said Bill Walker, vice president of the Environmental Working Group. PFOA is part of a broader constellation of substances known as perfluorinated chemicals, or PFCs. When PFCs are heated, they break down into compounds that can be absorbed into food and make it into the bloodstream. Federal investigators determined in 2005 that PFOA is a "likely carcinogen" and called for expanded testing to study its potential to cause liver, breast, testicular and pancreatic cancer. Walker at the Environmental Working Group said the voluntary phaseout supported by the EPA was insufficient. It wouldn't apply to Chinese companies, which are among the leading manufacturers of food packaging.
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It's likely that most people have never heard of Gaucho. And no, it's not a South American cowboy. I'm talking about a pesticide. There is increasing reason to believe that Gaucho and other members of a family of highly toxic chemicals -- neonicotinoids -- may be responsible for the deaths of billions of honeybees worldwide. Some scientists believe that these pesticides, which are applied to seeds, travel systemically through the plant and leave residues that contaminate the pollen, resulting in bee death or paralysis. The French refer to the effect as "mad bee disease" and in 1999 were the first to ban the use of these chemicals, which are currently only marketed by Bayer (the aspirin people) under the trade names Gaucho and Pancho. Germany followed suit this year. So why did the U.S. Environmental Protection Agency in 2002 grant an "emergency" exemption allowing increased use of Gaucho -- typically invoked during a major infestation -- when only a few beetles were found in blueberries? Why did the agency also grant a "conditional" registration for its close relative, Pancho, allowing the chemical on the market with only partial testing? And why is the agency, hiding behind a curtain of "trade secrets," still refusing to disclose whether the additional tests required of companies in such cases were conducted and, if so, with what results? [Pesticides] are regulated ...- under the antiquated Federal Insecticide, Fungicide and Rodenticide Act. This law allows a chemical on the market unless it's proved to pose "an unreasonable risk," far too weak a standard.
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Between 1983 and 1999, men’s life expectancy decreased in more than 50 U.S. counties, according to a recent study by [Majid] Ezzati, associate professor of international health at the Harvard School of Public Health (HSPH), and colleagues. For women, the news was even worse: life expectancy decreased in more than 900 counties—more than a quarter of the total. This means 4 percent of American men and 19 percent of American women can expect their lives to be shorter than or, at best, the same length as those of people in their home counties two decades ago. The United States no longer boasts anywhere near the world’s longest life expectancy. It doesn’t even make the top 40. In this and many other ways, the richest nation on earth is not the healthiest. Poor health is not distributed evenly across the population, but concentrated among the disadvantaged. But in the United States, the gap between the rich and the poor is far wider than in most other developed democracies, and it is getting wider. That is true both before and after taxes: the United States also does less than most other rich democracies to redistribute income from the rich to the poor. Living in a society with wide disparities—in health, in wealth, in education—is worse for all the society’s members, even the well off. People at the top of the U.S. income spectrum “live a very long time,” says Cabot professor of public policy and epidemiology Lisa Berkman, “but people at the top in some other countries live a lot longer.”
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What would you do if had an incurable disease and heard that something simple and common may help -- a chemical found at a pet store, or in an allergy drug, or a breakthrough injection a man in California developed? It's the sort of dilemma Alan Romantowski, a former airline pilot, faces with each news story about Alzheimer's disease treatments. "It is tempting; I'm taking ginseng, fish oil, ginkgo and all the over-the-counter things that the doctors say don't have any proof that it helps, but it doesn't hurt," said Romantowski, 55, who is suffering from the early stages of the disease. Whether scientifically sound or wacky, any news about potential Alzheimer's treatments can fill a doctor's voicemail with calls from desperate families. And a new potential treatment announced Tuesday may be no exception. Discussed at the annual Alzheimer's Association Meeting in Chicago, a drug called Rember sparked hope among researchers and within the Alzheimer community. Rember has completed a phase II trial, which means it's a long way off from meeting FDA approval as a legal therapy. But, thus far the data has shown promise -- double the improvement in cognition than a placebo gives for patients with moderate Alzheimer's disease. "There was an article about that in our paper this morning," said Josie Romantowski. "I actually even called my husband about it... as far as trying [a drug], what is there to lose really, at this point?"
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The head of a prominent cancer research institute issued an unprecedented warning to his faculty and staff: Limit cell phone use because of the possible risk of cancer. The warning [came] from Dr. Ronald B. Herberman, director of the University of Pittsburgh Cancer Institute. Herberman is basing his alarm on early unpublished data. He says it takes too long to get answers from science and he believes people should take action now — especially when it comes to children. "Really at the heart of my concern is that we shouldn't wait for a definitive study to come out, but err on the side of being safe rather than sorry later," Herberman said. [His] advice is sure to raise concern among many cell phone users and especially parents. In the memo he sent to about 3,000 faculty and staff, he says children should use cell phones only for emergencies because their brains are still developing. Adults should keep the phone away from the head and use the speakerphone or a wireless headset, he says. He even warns against using cell phones in public places like a bus because it exposes others to the phone's electromagnetic fields. Herberman cites a "growing body of literature linking long-term cell phone use to possible adverse health effects including cancer." "Although the evidence is still controversial, I am convinced that there are sufficient data to warrant issuing an advisory to share some precautionary advice on cell phone use," he wrote in his memo.
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Important Note: Explore our full index to revealing excerpts of key major media news stories on several dozen engaging topics. And don't miss amazing excerpts from 20 of the most revealing news articles ever published.